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. 1995 Dec 1;36(4):499–508. doi: 10.1186/BF03547664

Hematological and Blood Biochemical Effects of Fasting and Subsequent Oral Administration of Endotoxin in Prepubertal Gilts

Hematologiske och blodkemiska effekter avfasta och därpå följande oral administrering av endotoxin hos svin

H Holst 111,✉, H Kindahl 211
PMCID: PMC8095436  PMID: 8669377

Abstract

The main objective of the present study was to investigate the effects of short-term fasting in gilts on endocrinological and blood biochemical parameters and, further, the effects of subsequent oral endotoxin (ET) administration. Group 1 was fasted for 30 h and then received feed with ET added. Group 2 was fasted for 30 h but received standard feed at refeeding. In group 3, gilts were fed every 6 h for 30 h. The major effects of fasting were: gradually increased concentration of plasma prostaglandin F2α metabolite, serum total bilirubin, serum free fatty acids, and decreased serum glucose. The values were normalized within 1–4 h of refeeding. Twelve hours after refeeding, the ET-refed gilts showed higher levels of serum total bile acids and polymorphonuclear leukocytes than those in group 2. It is possible that the observed changes during fasting reflect either an increased intestinal uptake of naturally present endotoxin or a reduced endotoxin detoxifying capacity of the liver. The increased bile acid concentration and polymorphonuclear leukocyte count following refeeding with ET-feed may indicate that orally administered ET is to some extent absorbed from the gut.

Keywords: prostaglandin

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Acknowledgments

The present study was supported by the Swedish Council for Forestry and Agricultural Research, the Farmers’ Research Council for Information and Development, and the Michael Forsgren Foundation.

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