Skip to main content
EMBO Reports logoLink to EMBO Reports
. 2021 Apr 19;22(5):e52895. doi: 10.15252/embr.202152895

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened

Zhonghua Zhao, Raymond Teck Ho Lee, Ganesh V Pusapati, Audrey Iyu, Rajat Rohatgi, Philip W Ingham
PMCID: PMC8097361  PMID: 33949092

Abstract

graphic file with name EMBR-22-e52895-g001.jpg


As described on page 742 of the abovementioned paper, we identified two further putative GRK2 phosphorylation sites within the mSmo CTT in addition to the 12 previously described by Chen et al (2011); regrettably however, due to an oversight in the preparation of the final version of our manuscript, we omitted to provide the following details of these sites: S698 and S748. Both of these Ser are mutated to Ala in the mSmo14A construct that we refer to. We would also like to make it clear that our mSmoSA, in which the 12 sites identified by Chen et al (2011) are mutated, is equivalent to the mSmoSA0‐5 described by these authors.

Correction to: EMBO Reports (2016) 17: 739–752. DOI 10.15252/embr.201541532 | Published online 4 April 2016

Reference

  1. Chen Y, Sasai N, Ma G, Yue T, Jia J, Briscoe J, Jiang J (2011) Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol 9: e1001083 [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from EMBO Reports are provided here courtesy of Nature Publishing Group

RESOURCES