Figure 1. Flow of Patients in the ARCTIC REWIND csDMARD Study.

ACR indicates American College of Rheumatology; csDMARD, conventional synthetic disease-modifying antirheumatic drugs; DAS, Disease Activity Score; and EULAR, European Alliance of Associations for Rheumatology.

^aRemission according to established criteria should be documented for at least 12 months.

^bDAS is a composite measure of disease activity with scores ranging from 0 to 10, higher scores indicate more disease activity, remission defined as <1.6.

^cStratified by study site.