Age‐associated changes in the blood‐brain barrier: comparative studies in human and mouse

Following the publication of the above article in Neuropathology and Applied Neurobiology 44: 328–340; April 1, we would like to correct the axis labels of Figures 4 D,F and 5 B,D. The axis labels should reflect ‘Age (years)’ instead of ‘Age (months)’.

Figure 4.

Age‐associated changes in glial pathology. (A) GFAP immunolabelling of astrocytes in the mouse brain. (B) GFAP area immunoreactivity correlates with age in all but the youngest age group of the mouse cohort (P = 0.016). (C) GFAP immunolabelling of astrocytes in the human brain. (D) In the ageing human cohort, semiquantitative assessment of gliosis in the cortex expression demonstrates an association with age (P = 0.003). (E) Iba‐1+ microglia in the human brain. (F) In contrast to GFAP, no age‐associated changes in Iba‐1 expression were detected. Scale bar represents 50 lm in A,C,E.

Figure 5.

Age‐associated changes in vascular pathology. (A) CD31 immunolabelling of cerebral vessels in the human cortex. (B) No significant age‐associated changes in microvascular density were detected. (C) PCGFRb+ pericytes (brown) are intimately associated with vessels (PAS, red). (D) There was no significant difference in the pericyte coverage of vessels in the youngest vs. the oldest group. Scale bar represents 50 lm.

We have now changed the axis labels in the above mentioned figures and the correct figures are shown below.

We apologize for this error.