Ambery C, Young G, Fuller T, Lazaar AL, Pereira A, Hughes A, Ramsay D, van den Berg F and Daley‐Yates P. Pharmacokinetics, Excretion, and Mass Balance of [14C]‐Batefenterol Following a Single Microtracer Intravenous Dose (Concomitant to an Inhaled Dose) or Oral Dose of Batefenterol in Healthy Men. Clin Pharm Drug Dev. 2018;7:901–910. https://doi.org/10.1002/cpdd.616
There were errors in the Results section (post‐hoc analysis) and Online Supplement of the above paper.
The text should read:
Results: A post hoc analysis comparing the ratio of total drug‐related material in the systemic circulation to parent drug using combined data from Periods 1 and 2 (IV and oral administrations) made it possible to calculate the fraction of the drug surviving first‐pass gut wall metabolism (Fg; 27%), the hepatic extraction ratio (EH; 44%), and the fraction of the drug absorbed via the gut following oral administration (Fabs; 0.0008%). Details of the calculation are provided in the Online Supplement.
Online Supplement:
Absolute bioavailability (Table 3): F0‐t = 0.012%
Based on AUC0‐t values from (Table 2): MLIV = (122 − 104)/122 = 0.1475
MLoral_pooled = (260 − 0.614)/260 = 0.998
CL = QH × EH; CL = 37.9 L/h (Table 2) → EH = CL/QH = 37.9/87.0 = 0.436 (i.e. 44%); hepatic extraction4 [thus Fh = 1‐EH = 56%]
Fg = (1 − (0.998 − 0.1475))/Fh = 0.27 (i.e. 27%); fraction of the drug surviving first‐pass gut wall metabolism
Fabs × Fg = F0‐t/(1 − EH) → Fabs × 0.27 = 0.012/(1 − 0.436) → Fabs = 0.08 (i.e. 0.0008%); fraction of the drug absorbed via the gut
EH, hepatic extraction ratio; ML, metabolite load; QH, hepatic blood flow