The Neuropathology of CAG Repeat Diseases: Review and Update of Genetic and Molecular Features

Yves Robitaille; Iscia Lopes‐Cendes; Mark Becher; Guy Rouleau; Arthur W Clark

doi:10.1111/j.1750-3639.1997.tb00893.x

. 2008 Jan 28;7(3):901–926. doi: 10.1111/j.1750-3639.1997.tb00893.x

The Neuropathology of CAG Repeat Diseases: Review and Update of Genetic and Molecular Features

Yves Robitaille ^1,^✉, Iscia Lopes‐Cendes ¹, Mark Becher ², Guy Rouleau ¹, Arthur W Clark ³

PMCID: PMC8098401 PMID: 9217975

Abstract

Classification of inherited neurodegenerative diseases is increasingly based on their genetic features, which supplement, clarify, and sometimes replace the older clinical and pathologic schemata. This change has been particularly rapid and impressive for the CAG repeat disorders. In Huntington's disease, X‐linked spinobulbar muscular atrophy, dentatorubropallidoluysian atrophy, and a series of autosomal dominant cerebellar atrophies, genetic advances have resolved many nosologic issues, and opened new avenues for exploration of pathogenesis. In this review, we summarize classic and current concepts in neuropathology of these CAG repeat diseases.

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The Neuropathology of CAG Repeat Diseases: Review and Update of Genetic and Molecular Features

Yves Robitaille

Iscia Lopes‐Cendes

Mark Becher

Guy Rouleau

Arthur W Clark

Abstract

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PERMALINK

The Neuropathology of CAG Repeat Diseases: Review and Update of Genetic and Molecular Features

Yves Robitaille

Iscia Lopes‐Cendes

Mark Becher

Guy Rouleau

Arthur W Clark

Abstract

Full Text

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