Table 1.
Demographics and Tumor Characteristics
| |
FVPTC |
NIFTP |
|
|---|---|---|---|
| n | n = 95, foci = 113 | n = 15, foci = 19 | p |
| Male, n (%) | 21 (22) | 4 (27) | NS |
| Mean age (years) | 48 (SD 16) | 49 (SD 11) | NS |
| Race/ethnicity, n (%) | NS | ||
| White | 48 (49) | 10 (66) | |
| Black | 23 (24) | 3 (20) | |
| Hispanic | 13 (14) | 1 (7) | |
| Asian | 9 (10) | 1 (7) | |
| Other/unknown | 2 (2) | 0 | |
| Mean diameter (cm) | 2.2 (SD 1.7) | 1.7 (SD 0.85) | NS |
| Total thyroidectomy | 96% (88 TT, 4 CT) | 93% (12 TT, 2 CT) | NS |
| Lobectomy, n (%) | 3 (4) | 1 (7) | NS |
| Node dissection, n (%) | NS | ||
| Central node | 39 (42) | 3 (20) | NS* |
| Lateral node | 8 (8) | 0 | |
| No dissection | 48 (50) | 12 (80) | |
| Metastases at initial diagnosis (total) | 19 | 0 | NS* |
| Central nodes, n (%) | 6 (6) | 0 | |
| Lateral nodes, n (%) | 8 (8) | 0 | |
| Distant, n (%) | 4 (4) | 0 | |
| 1 bone/3 lung | |||
| Multifocal, n (%) | 15 (16) | 4 (27) | NS |
| BRAFV600E positive | 19% (43 tested, 8 positive) | 0% (6 tested, 0 positive) | NS |
The presence of a microcarcinoma did not qualify a patient as having a multifocal process, which was defined in this analysis as the presence of an additional cancer (or NIFTP) ≥1.0 cm.
*
For nodal dissections and presence of metastases, the Fisher exact tests were calculated for any node dissection vs. no node dissection and for any metastases vs. no metastases.
CT, completion thyroidectomy; FVPTC, follicular variant of papillary thyroid carcinoma; NIFTP, noninvasive follicular thyroid neoplasm with papillary-like nuclear features; NS, not significant; SD, standard deviation; TT, total thyroidectomy.