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. 1994 Jun 1;35(2):155–163. doi: 10.1186/BF03548343

Field Trials with a New Genetically Engineered Vaccine for Protection Against Progressive Atrophic Rhinitis in Pigs

Khnisk afprøvning med gen-splejset vaccine mod nysesyge (PAR) hos svin

A Bording 17,27,✉, K Nymark 27, E Smidt 27
PMCID: PMC8101366  PMID: 7942381

Abstract

Bording, A., K. Nymark, E. Smidt: Field trials with a new genetically engineered vaccine for protection against progressive atrophic rhinitis in pigs. Acta vet. scand. 1994, 35, 155-163.–Field trials were carried out testing a new genetically engineered vaccine against Progressive Atrophic Rhinitis. The vaccine contained a non-toxic recombinant derivative of the P. multocida toxin. The experimental vaccine was compared with a commercial vaccine in 4 farms and in 1 farm 2 different dose regimens were applied. A total of 825 sows were included. The primary efficacy variable was a comparison of post mortem evaluation of the degree of conchae atrophy in the 4585 pigs. The pigs were slaughtered at normal slaughter weight. The secondary efficacy variables were serological response and age at slaughter. In all farms the experimental vaccine provided significantly better protection of the progeny than the control vaccine. The serological response in sows was significantly higher in all farms than the response to the control vaccine. The serological response did not differ between farms.

Keywords: vaccination, Pasteurella multocida, toxin, derivative

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Acknowledgments

The authors wish to thank the veterinarians and the farmers and the slaughter houses making these field trials possible. The superb assistance provided by the technicians Anders Wamsler and Lis W. Johannsen is greatly appreciated.(Received July 19, 1993; accepted February 21, 1994).

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