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. 1994 Sep 1;35(3):283–288. doi: 10.1186/BF03548333

Influence of Medetomidine on Acid-base Balance and Urine Excretion in Goats

M Raekallio 18,✉, M Hackzell 28, L Eriksson 28
PMCID: PMC8101369  PMID: 7847197

Abstract

Raekallio M., M. Hackzell and L. Eriksson: Influence of medetomidine on acid-base balance and urine excretion in goats. Acta vet. scand. 1994,35,283-288.– Seven goats were given medetomidine 5 μg/kg as an iv bolus injection. Venous blood samples were taken repeatedly and urine was collected continuously via a catheter up to 7h after the injection.

Medetomidine caused deep clinical sedation. Base excess, pH and PCO2 in venous blood rose after medetomidine administration. There were no significant changes in plasma concentrations of sodium, calcium, magnesium, creatinine or osmolality, whereas potassium and bicarbonate concentrations increased, and phosphate and chloride decreased. Medetomidine increased plasma glucose concentration, and in 4 of 7 goats glucose could also be detected in urine. Medetomidine did not influence urine flow rate, free water clearance, bicarbonate and phosphate excretion or pH, but renal chloride, sodium, potassium, calcium, magnesium and creatinine excretion were reduced.

The results suggest that the metabolic alkalosis recorded after medetomidine administration is not caused by increased renal acid excretion.

Keywords: metabolic alkalosis, base excess, bicarbonate

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Acknowledgments

This study was supported by the Finnish National Research Council for Medical Sciences (Project No 1091008).

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