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. 1994 Sep 1;35(3):235–241. doi: 10.1186/BF03548328

Effects of the Long-acting Somatostatin Analogue Octreotide on Abomasal Function and Plasma Level of Insulin and Glucagon in Sheep

K Holtenius 1,✉
PMCID: PMC8101415  PMID: 7847192

Abstract

Holtenius, K.: Effects of the long-acting somatostatin analogue octreotide on abomasal function and plasma level of insulin and glucagon in sheep. Acta vet. scand. 1994, 35, 235-241.– The effects of the long-acting somatostatin analogue octreotide were studied in sheep. Octreotide was given subcutaneously at a dose of 0.75 ug/kg body-weight and, as a control, 0.9% saline solution was injected in a change-over design. Octreotide inhibited abomasal acid secretion and retarded the turnover time of digesta through the abomasum. The plasma levels of insulin and glucagon decreased due to the octreotide injection, while the plasma glucose level was not affected. The effects of octreotide lasted for 3-4h. There were no significant effects of the saline injection. The effects of octreotide showed similarities with results from previous studies on monogas-tric species.

Keywords: inhibitory effects, abomasal pH, abomasal fluid turnover time, glucose production

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Acknowledgments

The author is grateful to Mrs. Vendula Hatasova for excellent technical assistance.

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