Comparing the total monthly numbers of out-of-hospital cardiac arrest (OHCA) for March, April, May and June 2020 to the average of the corresponding monthly totals for the prior two years (2018–2019), the percent change in monthly totals of OHCA cases from those prior years (y-axis) are displayed for each of 50 major U.S. cities (x-axis) during the months of March through June, respectively. Deviations of greater than 10% from prior years were deemed significant, both statistically and operationally. The red lines delineate cities with greater than 20% increases in OHCA over prior years.