Figure 4.

Tumor cell death enhanced CD103⁺ Ti-DC migration to dLNs is inhibited by ATP-P2X7R, HMGB1-TLR4, Gαi-protein, and S1PR1 pathway blockade

Inhibitors were administrated together with DT at the time of tumor photoconversion and analyzed 24 h later. A number of KikGR-Red cells in total migratory DCs and DC subsets in dLNs. Bar graph shows means ± SEM of pooled data from at least two independent experiments (n = 8-16). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (one-way ANOVA with Holm-Sidak's multiple comparisons test).