Minimally Invasive Surgery for the Treatment of Ureteric Stones – State-of-the-Art Review

Abstract

The landscape of managing ureteric stones has evolved over the last few decades and several treatment options exist depending on the stone size, location, and other patient and stone factors. While open surgery is now rarely performed, the use of medical expulsive therapy (MET) has been controversial and perhaps only recommended for large distal ureteric stones. The mainstay treatment balances between shockwave lithotripsy (SWL) and ureteroscopy (URS), with the latter usually recommended for larger stones. While the principles of ureteric stone management have remained largely unchanged, the modern era has generated new methods and means to deliver it. Advancements have occurred in all domains of endourology to try and refine treatment and balance it with cost, patient choice and quality of life. Dissemination of technologies and demonstration of their efficacy and safety will eventually result in new recommendations among international guidelines and evolution of new gold standards.

Introduction

The landscape of treatment for ureteric stone disease has evolved dramatically over the last 50 years. Historically, stone treatment was limited to interventions such as open surgery, but the evolution of minimally invasive surgery and the birth of endourology has led this to change. The story of endourology has had many chapters so far. Key milestones in this timeline include the first report of intra-ureteral lithotripsy in 1979 and the introduction of the flexible ureteroscope by Bagley et al in 1983.1,2 Research and development of new technologies has been a driving force for this change. Urolithiasis has a lifetime global prevalence of 14% and population-based studies reveal that this is rising.3,4 The underlying causes for this global change are considered multifactorial and relate to both host and environmental factors such as obesity, diabetes, smoking, climate change among many others.5–7 The burgeoning incidence of stone-related events has led to greater volume in stone surgery worldwide. Meta-analysis by Geraghty et al revealed the number of URS treatments has risen by over 250% over the past twenty years.8

From the urologist’s perspective, there are a plethora of treatment modalities and modifications, which can be employed in order to deliver a “state-of-the-art” treatment to patients. These choices depend on a number of variables such as stone size, location and composition as well as surgeon experience and personal preference. Staying up to date with the inexorable rise in new endourology research can be challenging for the busy clinician and this scoping review serves to provide such an update. Advancements in SWL, URS as well as laparoscopic techniques for the treatment of ureteric stone disease are addressed.

Shockwave Lithotripsy (SWL)

Using ‘shock waves’ or acoustic pulses to fragment stones, which are located using either fluoroscopic or ultrasonic imaging, was introduced by Dornier, a German aircraft cooperation in 1980 during the investigation of pitting on supersonic aircraft. Since its first clinical application by Chaussy et al, the Human Model-1 (HM-1) lithotripter has undergone multiple revisions. Systems can now employ electrohydraulic, piezoelectric and electromagnetic generators.9 The advent of mobile, multifunctional lithotripters has expanded the treatment possibilities for ureteric stones. This has rendered SWL more accessible to smaller centres and more available in the acute setting. The latter being often referred to as “hot lithotripsy”. A criticism of using mobile lithotripters is that efficiency such as overall stone free rates (SFRs), is poorer in comparison to results achieved with a fixed lithotripter.10 Current European Association of Urology (EAU) guidelines recommend SWL as a 1st line treatment for both proximal and distal ureteric stones for stones <10mm (2nd line for stones >10mm).11 There is evidence that stones located in the middle third of the ureter can be difficult to localise and therefore treated effectively. However, American Urological Association (AUA) guidelines concluded that SWL does provide stone clearance in the proximal, middle and distal ureter with a stone free rate (SFR) of 82%, 73%, and 74%, respectively.12 In addition to its less invasive nature, SWL in adults does not require GA and is therefore a treatment option to consider in patients with a high anaesthetic risk profile. Owing to their radiolucency, uric acid calculi require ultrasound (US) or fluoroscopy with contrast to locate the stone accurately and ensure correct shockwave placement.

SWL is less effective for treatment of cystine stones and identification of the stone at time of SWL can be challenging in obese patients, which reinforces how important careful patient selection is. Complications include abdominal pain, haematuria, sepsis, perirenal haematoma and obstruction caused by fragments in the ureter (“steinstrasse”).10 Analgesia at the time of SWL is recommended and there is potentially a role for tamsulosin post-procedure to aid in the passage of stone fragments and to help relieve any discomfort or pain.11,12 Post-operative imaging is required within the first month (in the form of plain radiography ± US) and should be expedited if a patient is symptomatic, although CT scan is preferred in some centres.

Recent Advances

Compared to alternative endourological treatments, there have not been many advancements to the underlying technology since its first description. However, SWL has received attention and has undergone modifications in order to yield better outcomes. Jagtap et al conducted a large series, which identified several factors that may contribute to improved SFR in the context of SWL.13 These included better stone localisation, improved coupling, a revision of the current patient and stone selection criteria, reducing shock wave rate and ramping energy, coupled with enhancing lithotripter training. Recent reports have brought attention to prediction models and nomograms and there is emerging evidence highlighting the role of novel urinary biomarkers when identifying or predicting infection or haemorrhage post SWL.14,15

Ureteroscopy (URS)

URS serves both diagnostic and therapeutic purposes. From early cases performed using a paediatric cystoscope, the development of the ureteroscope has come a long way. In 1960, the scope design was revolutionised with the rod lens system, which allowed smaller diameter rigid scopes to be used for URS. The early 1980s saw modelling of the first semi-rigid ureteroscope and its application to remove ureteric calculi for the first time harnessing separate optic and working channels.16 Thereafter, with the miniaturisation of scopes, improved durability, and the application of lithotripsy during URS the worldwide popularity of endoscopy has risen and now surpasses that of SWL.8 EAU guidelines recommend URS for both proximal and distal ureteric stones. Furthermore, it is recommended as the first line in cases of stones >10mm size. In contrast to its counterparts, there are no reported contraindications to URS.11 For example, it can be employed as a safe alternative for obese patients and those with bleeding diatheses.17 URS has a low overall complication rate of less than 10% according to most studies and while it is considered a relatively safe procedure it has been associated with rare, fatal outcomes, mostly linked to sepsis.18,19 The most frequently reported complications associated with URS are pain and infection.19 In order to reduce complications associated with high intrarenal pressures, recent times have seen a novel type of flexible URS (f-URS) being introduced, which displays both pressure-controlled feedback irrigation systems and suctioning mechanisms. These have been shown to treat even larger upper tract stones safely.20 Overall costs of URS versus SWL, demonstrate the former is more cost-effective ($2801) compared to SWL ($3627) (p = 0.03).21

Primary vs Delayed URS

There is a growing argument supporting the role of primary URS (p-URS) rather than delayed or expectant management of ureteric calculi. The risk of delaying definitive management can exacerbate the existing financial and clinical burden of urolithiasis or complications associated with it.22 As rates of URS increase globally, the use of p-URS in the acute setting is also likely to rise. A recent study found no significant differences in terms of operative times, need for postoperative stenting, SFR and complications, between p-URS and delayed URS (d-URS) (which involved initial management with ureteric stenting only).23 This suggests that in future the role of p-URS and immediate stone removal is likely to be considered over delayed management with stenting. However, there might be a higher failure rate of p-URS, and they are generally not recommended in patients with active urinary tract infection.23

Scope Design

Numerous developments in instrumentation have facilitated even safer access to the upper urinary tract through use of both semi-rigid and flexible ureteroscopes. The former is well suited for examination of the distal ureter as they can be easily advanced under vision into the ureteric orifice, allow superior image transmission, provide stability of working instruments and larger working channels. This means higher irrigation pressures can be adopted, which may deliver better views. Semi-rigid URS provides an overall stone clearance rate exceeding 80% and is particularly successful for treatment of distal ureteric stones.24 Over the last few decades, the design of these scopes has changed to become longer, thinner and now even enables access to proximal ureteric stones.25

Flexible ureteroscopes (fURS), on the other hand are well designed for upper ureteric and intrarenal stones and as their name suggests, their angles can be manipulated to match to natural course of the ureter. For proximal ureteric stones, they achieve a higher SFR when compared to semi-rigid URS but do not differ significantly in complication rates.26 There are fiber-optic or digital flexible ureteroscopes. The former has a smaller diameter, better deflection and is cheaper. Digital scopes hold the advantage of producing higher quality images and do not require additional light cables or camera heads. Since the development of miniaturised, flexible and digital scopes, both access and stone visualisation has vastly improved. Miniaturisation of scopes has expanded the indications to now include stone removal in transplant kidneys. Early fURS models were associated with loss of the maximum active deflection angle upon insertion of accessories such as guidewires. The advent of ureteroscopes with active secondary deflection or continuous deflection to 270 degrees has improved this, which is particularly important where there is an acute infundibulopelvic angle (IPA).26 Incorporating a dual working channel in f-URS facilitates continuous irrigation flow in conjunction with insertion of ancillary instruments. This has allowed improved visibility when compared with single-channel ureteroscopes and may give rise to new procedural opportunities. One of latest developments in flexible ureteroscope design are single-use scopes (su-fURS), which hope to combat issues of reprocessing, contamination and costly repairs.27 There have been proposals for a “mixed strategy”, which integrates the use of both su-fURS and re-fURS. This may prevent re-fURS from unnecessary breakages and allow challenging anatomical cases (eg, steep IPA, which is considered a risk factor for scope damage) to be tackled by su-fURS (Table 1). Further cost-effectiveness analyses are needed to ascertain the economic profile of widespread su-fURS use. Furthermore, future studies are warranted, which assess the environmental impact of su-fURS compared to re-fURS. While the former generates more plastic waste, the latter incurs greater energy consumption due to reprocessing. As awareness surrounding climate change is increasing, there will be a greater social responsibility for clinicians to re-evaluate the carbon footprint associated with their practice.

Table 1.

Overview of Ureteroscopes (*Not Exhaustive List)

Type of Ureteroscope	Advantages	Disadvantages	Manufacturer*	Name – Examples*
Re-usable Semi rigid ureteroscope	- Allows treatment of all locations of ureteral stones -Relatively less expensive	-Difficult to negotiate in tortuous and tight ureter(s)	Olympus Wolf	OES PRO rage Needle/Ultra-thin/D.O.C
Single use semi-rigid ureteroscope	Lightweight	-Limited to one commercially available type. -No studies reporting its use	Neoscope	Neoscope
Reusable flexible ureteroscope	- Allows treatment of all locations of stones in the kidney and mid/proximal ureter -In vitro studies reveal better field of view	-Prone to damage and costly repairs -Re-processing is costly, time consuming and labour intensive	Olympus Lumenis Storz Wolf	URF-V3/V/P6/P7 Polyscope FLEX-Xc/X2(S) Cobra/Boa/Viper
Single use flexible ureteroscope	-Light weight and digital technology -In vitro studies reveal better deflection and irrigation properties -May be better for surgical training due to less overall breakage costs.	-Costly to buy upfront -Worse ecological impact -May be worse for visualising upper tract tumours	Boston Scientific Pusen Maxiflex Neoscope Innomedicus YouCare Technology Co. Dornier Med-Tech	LithoVue Uroscope SemiFlex NeoFlex WIScope ShaoGang AXIS

Endourological Armamentarium

Guidewires

Guidewires are an integral tool in endourology. Advantages include improved negotiation of tortuous ureteric segments, overcoming strictures and bypassing impacted stones. The use of safety guidewires during URS has been occasionally debated.28 A key advantage they offer is the option to insert a ureteral stent and abort the procedure, should complications arise.

There is a range of guidewires available including hybrid models, which hold differences in shaft stiffness, lubricity and tip configuration.29 For instance, flexible hydrophilic-tip wires facilitate access beyond the obstruction with a low risk of perforation, while stiffer shaft wires are designed for difficult ureteral catheterisations, reducing kinking and ureteral access sheath (UAS) or stent insertion.30 The use of a safety wire is recommended for all ureteroscopy procedures, although it is not mandatory in expert hands.11

Working Instruments and Ureteral Access Sheath (UAS)

The rise in popularity of URS is in part due to improvements in the quantity and quality of working instruments available. These include different styles and sizes of grasping forceps and baskets, which have all been developed to ameliorate safe extraction. UASs, which serve to avoid trauma associated with repeat passage along the course of the upper urinary tract, are a subject of significant discussion.31 Reported benefits include improved visibility, reduced operative time, reduced need for high intrarenal pressure and a potential reduction in subsequent complications (infectious or haemorrhagic) as a result (Table 2). However, there are several studies highlighting the limitations of UAS usage. For example, their application may not necessarily correlate with improved SFR.32 Prolonged duration of UAS time may be associated with greater post-operative pain.33 Selection of optimal size and length of UAS is dependent on the user, and often dictated by the compliance of the ureter. Its use is easier in pre-stented ureters and a shorter length (35cm) is generally preferred in females and paediatric patients, while a longer length (45cm) is preferred for male patients.11

Table 2.

Overview of New Technologies (*Not Exhaustive List)

Technology	Example/Manufacturer*	Description	Advantages	Disadvantages
Thulium Fiber laser (TFL)	SOLTIVE (Olympus) Fiberlase (NTO IRE-Polus)	Novel laser technology with properties which should allow more efficient lithotripsy and reduced photothermal damage to other structures. Uses laser diode rather than flash lamp.	-Less retropulsion -Higher frequency range (up to 2400Hz) -Faster stone ablation rate	-Lack of randomised trials -No cost data
Moses Homium laser	Moses technology (Lumenis) Vapor Tunnel (Quanta system)	Novel modulation of laser pulse allows improved stone fragmentation as a result of better transmission of energy in water	-Increases ablation rate -Reduces retropulsion	-Limited clinical studies on technology -Higher cost
Anti retropulsive devices (ARDs)	Stone Cone/Escape/Lithocatch/ Parachute (Boston Scientific) NTrap (Cook Medical) Accordion (Endotherapeutics) XenX (Xenolith Medical)	Prevent retrograde migration of stone fragments during lithotripsy	-Reduced retropulsion rate -Potential to reduce retreatment rate	-Added cost of procedure (may be offset by reduced need additional procedures) -Some devices liable to damage from laser -Some devices not wide enough for use dilated ureter(s)
Ureteral access sheath (UAS)	Flexor (Cook Medical) UroPass (Olympus) Bi-Flex Evo (Rocamed) Navigator (Boston Scientific)	Allow repeat access to kidney with ureteroscope	-Decrease intrarenal pressure -Repeat and rapid entry to renal pelvis -Improved visibility -Reduced operative time	-Placement can be difficult -Intra-operative complications eg, tear, perforation -Post-operative complications eg, stricture -Over dilation for insertion

Stents

Stents are available in various sizes, materials and designs. The main types available are polymeric, metal or biodegradable.34 Post-operative stenting is indicated in cases of impacted ureteric calculi, ureteric perforation, solitary kidneys, pregnancy and retroperitoneal fibrosis. Fluoroscopic ± cystoscopic confirmation of stent position should be performed. There is currently no universal consensus on the recommended duration for post-operative stenting, but standard practice is generally 1 to 2 weeks. Common issues associated with ureteric stents are pain, infection, encrustation and migration. Various treatment options exist for stent-related symptoms including simple and narcotic analgesia, anti-inflammatory medications, alpha-blockers and anti-cholinergics. If symptoms persist, ultimately stent removal may be required. Modern designs include stent on a string which are cost-effective, which can ensure a reduced indwelling time as well as allow the patient to remove the stent safely themselves at home.35 Magnetic tipped stents have been designed to mitigate the need for cystoscopic stent removal.36 Current evidence appears promising, as they seem to be associated with fewer pain symptoms and have been shown to be cost-effective. Forgotten stents are a serious complication with a rate of up to 12.5%.37 Many institutions adopt a “stent register” to combat this complication. More recent developments have included the use of smartphone apps (eg, Urostentz) to monitor this.38 Drug-eluting stents are a relatively recent advancement that aims to reduce stent-related symptoms by delivering medication locally. There are reports showing promising results in terms of lowering pain and voiding symptoms, however further studies are required to validate their use against increased cost.34 Patient reported outcome measures (PROMS) can be employed in order to assess patient symptoms related to the stent such as Ureteral Stent Symptom Questionnaire (USSQ).39 There also exists a PROMs designed to specifically assess symptom burden associated with ureteric stones, the Cambridge Ureteral Stone PROM (CUSP).40

Biodegradable stents are currently under investigation and in theory will be able to minimise issues related to stent removal. They may have the potential to also act as a vehicle for local drug delivery. Earlier generations of biodegradable stents were prone to incomplete degradation, and ultimately required removal of fragments making them unsuitable options.

Several in-vivo studies have looked at new materials and methods of biodegradable stent production and have shown promising results. These have included poly-lactic-co-glycolic acid (PLGA)/poly-caprolactone, natural polysaccharides, and novel stent shapes with an anti-reflux mechanism that lack the distal coil.41 There is also increasing recommendation and use of URS without the use of post-operative stents. It is generally believed that stents are not needed in uncomplicated ureteroscopy, thereby avoiding ‘stent symptoms’ and complications associated with it.11

Lasers

From the first pulsed dye laser, to the now globally used Holmium: yttrium-aluminium-garnet (Ho:YAG) laser and now with the advent of Thulium fiber laser (TFL), this area remains a hot topic in endourology. Depending on surgeon preference, stone burden and location, varying techniques can be adopted during laser lithotripsy. Recent laser advancements have enabled “dusting” through high frequency and low-power settings, which obviates need for basket retrieval.42 Reports show that dusting using thin laser fibres (273 micron) at low power (0.4–0.6 J) and high frequency (30–50 Hz) reduces the risk of retropulsion.43 Pietropaolo et al demonstrated successful outcomes of dusting and pop-dusting methods in patients with large calculi (>15mm). High SFRs were achieved, of 87% (after first procedure), followed by an increase to 92% (post-second procedure), which was only required in a minority of cases.44 The authors found improved rates of stone breakdown, reduced need for UAS and a low complication rate. While dusting and pop-dusting offer an appealing option in treating large, bilateral or multiple stones in a single setting, fragmentation with basket extraction has been previously deemed superior.45 Further studies will be needed to investigate whether dusting leads to greater stone recurrence rates, to clarify the follow-up post-dusting, and to compare outcomes (clinical and financial) with other methods of stone disintegration and removal. Current EAU Guidelines outline Ho-YAG laser as the gold-standard. It is effective in fragmenting stones of any kind and has improved the efficacy of intracorporeal lithotripsy.11 A new technique in Ho-YAG laser– the “Moses technology” is currently being investigated for its role in lithotripsy. Recent studies have demonstrated a significant reduction in stone retropulsion when compared with the conventional mode, without compromising ureteral tissue integrity.46 This may heighten the efficacy of lithotripsy as the stones move less. The Moses™ 200 D/F/L fibers are significantly more flexible, which facilitates their use in targeting stones in difficult locations by allowing further fURS deflection.

Thulium fiber laser (TFL) is a newer technology for stone ablation.47 It can reach pulse frequencies of up to 2,200 Hz (in contrast to 100Hz with Ho-YAG), a range of very low to very high pulse energies, short to very long pulse durations and a total power of up to 55W. TFL outperforms Ho: YAG in terms of stone ablation efficiency (it is four-times superior).48 Smaller laser fibers can be employed with TFL and this leads to improved irrigation, greater scope deflection, and it indirectly improves access, visualisation and operative time. The apparatus is approximately one-eighth the dimensions of the Ho:YAG laser system and it can be used with standard power outlet.

While still in use in some urological services, pneumatic and ultrasound systems do still serve a role in URS practice, but a common setback includes stone migration, which occurs in 5–40% of cases.49 This problem has been addressed through the development of coupling energy sources of lithotripsy with suction eg, LithoVac^®.50 Occlusion devices are techniques with dual function; they prevent stone migration and facilitate capture and removal of fragments.51 Their use in forms such as the “Stone Cone” is likely to increase as they mitigate the risk of stone migration, although it is not commonly used.52

Medical Expulsive Therapy (MET)

EAU guidelines acknowledge the potential benefit of MET to facilitate stone passage.11 Their effect on ureteric smooth muscle relaxation is thought to improve stone expulsion and aid in symptomatic relief. The advantages of employing MET as a treatment strategy involve a reduced cost burden by avoiding the need for surgery and a subsequent reduction in the associated risks of surgery and anaesthesia. Hollingsworth et al performed a meta-analysis of 55 randomised trials, which revealed that taking alpha-blockers significantly reduced pain episodes, time to stone passage and reduced risk of surgical intervention.53 However, the role of alpha-blockers in the context of MET still lacks consensus and as a result there is large variation in practice patterns worldwide.54

Conservative management of asymptomatic ureteric stones has a spontaneous passage rate of 64%.55 This rate for upper, mid and distal ureter was 49%, 58% and 68%, respectively, with 75% stones <5mm and 62% stones ≥5 mm passing spontaneously over a mean time of 17 days (range: 6–29 days). Conservative management has also been practiced in asymptomatic live donor kidney stones.56 Turgut et al have also evaluated the role of masturbation in spontaneous passage of distal ureteric stone.57

Ultrasonic Propulsion

Ultrasonic propulsion is a novel technique, which can be used pre or post both URS and SWL.58 It provides a safe and painless method for transcutaneous repositioning of stones. It has a promising role in facilitating the removal of residual fragments post-procedure and also in repositioning obstructing ureteropelvic junction stones into the kidney for symptomatic control of renal colic. As further clinical trials take place, and the technology is developed, it presents a promising approach to the treatment of ureteric stones in a non-invasive manner.59

Artificial Intelligence (AI)

The last decade has witnessed a paradigm shift harnessing artificial intelligence (AI) in the delivery and decision-making of patient care. AI has been widely used in Urology and has been shown to be accurate for prediction and analysis purposes.60 In the context of urolithiasis, the application of AI has allowed localisation of calculi (using computed tomography (CT)/US), detection of stone composition, prediction spontaneous stone passage and outcomes endourological procedures. With the increasing use of electronic databases, the role of AI is anticipated to expand further.

Endourological Training

The last two decades have seen a change in attitudes towards surgical skills training. From relying on a predominantly theoretical approach, more practical opportunities are now available with hands-on training through use of both mannequin and virtual reality simulators.61 These simulators have a unique role in enhancing a surgeon’s visuospatial, stress tolerance and psychomotor skills. Some simulators are now able to record and monitor errors and performance feedback can be given. Use of a standardised training model would optimise endourological treatment of ureteric stone disease.62

Several simulation models have been used for training including the Uro-Scopic Trainer (Limbs and Things, Bristol, UK), which is a bench trainer; Scope Trainer (Mediskills Ltd, Edinburgh, UK), also a bench trainer; and URO Mentor (3D Systems, Cleveland, OH, USA), a virtual reality simulator. Flexible ureteroscopy training models include the Key-Box (K-Box^®, Porgès-Coloplast, France) and the Cook URS Trainer (Cook Medical, Bloomington, IN, USA).63

Antegrade Ureteroscopy and Percutaneous Nephrolithotomy (PCNL)

Most international guidelines advocate use of antegrade URS in cases of large impacted ureteric calculi and for the removal of large stones in transplanted kidneys.11,12 In the setting of the latter, retrograde access can be challenging due to the anterior location of the ureteral anastomosis and tortuous ureteric anatomy. The use of a retrograde approach for this non-indexed patient population has a reported 28–60% incidence of stone retropulsion, which can lead to further secondary procedures and poor SFR.64 Antegrade URS avoids these risks and allows for improved visualisation and stone clearance. Disadvantages associated with the antegrade approach include increased operative time and hospital stay, higher radiation exposure and complications linked to the renal puncture.65 A recent meta-analysis concluded percutaneous nephrolithotomy (PCNL) to be the most efficient modality in the treatment of large proximal ureteric calculi.66 PCNL has been shown to achieve superior SFR when compared with the retrograde approach and is comparable with laparoscopic ureterolithotomy outcomes in terms of stone clearance, procedure time and length of postoperative stay.67

While the higher risk of bleeding is a recognised disadvantage associated with standard PCNL (24–30Fr), miniaturisation can mitigate this risk to a certain extent.68,69 Sheath sizes are now available as small as 4.85Fr. Mini-PCNL (<24Fr) has demonstrated improved outcomes in terms of bleeding, postoperative pain and length of hospital stay. Furthermore, its versatility allows for use with various lithotripter probes including ultrasonic, Ho:YAG and now even TFL.48

Ureteroscopy Under Local Anaesthetic

The current standard of care involves performing URS under GA. There have been concerns of potential ureteric injuries (eg, sudden patient movement) and patient intolerance when using a local anaesthetic (LA), however existing literature does not confirm this. A recent systematic review supported the practice of URS under LA.70 Overall SFR associated with local anaesthesia ranged from 48–100% while complication rates between LA and GA were comparable. Although mortality from URS is rare, there is a higher-risk patient population, who may be unfit for GA and who would be candidates for LA URS. Currently, SWL is the only alternative option for this cohort but is not necessarily suitable for all patients (eg, those on anticoagulation, larger stones). Although further randomised controlled trials are required to assess and compare outcomes of URS from alternative anaesthetic options, the future of LA URS looks promising and may offer a cost-effective and adaptable option for a certain subgroup of patients.

Ureterolithotomy

Ureterolithotomy has been occasionally used for large upper ureteral stones. A meta-analysis for URS vs ureterolithotomy showed higher SFR after the initial URS procedure, although the operative and hospital time were in favour of URS.71

Conclusion

While the principles of ureteric stone management have remained largely unchanged, the modern era has generated new methods and means to deliver it. Advancements have occurred in all domains of endourology. Dissemination of technologies and demonstration of their efficacy and safety will eventually result in new recommendations among international guidelines and evolution of new gold standards.

Disclosure

The authors reported no conflicts of interest for this work.