Fig. 4.

The interface structural comparison of two resolved human-SARS-cov2 structures. Both entry 6LZG (magenta) and 6M17 (green) are drawn from the Protein Data Bank (PDB) database. As an overall perspective, these two structures solved by cryo-electron microscopy are well agreement with each other. Some minor yet notable differences existed, nevertheless. Take hydrogen bonding interactions as an example, five additional hydrogen bonds exist in magenta structure, namely Q24-N487, D30-K417, E37-Y498, Q42-Q498 and Q42-G446, respectively. This suggests that even though the human-SARS-cov2 structures has been resolved, a single conformation is not provided adequate information because of the inherent structural fluctuation.