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. 1993 Sep 1;34(3):245–253. doi: 10.1186/BF03548188

Investigations on the Occurrence of Hereditary Diseases in the Danish Cattle Population 1989-1991

J S Agerholm 1,✉, A Basse 1, K Christensen 1
PMCID: PMC8112498  PMID: 8310897

Abstract

Agerholm, J.S., A. Basse and K. Christensen: Investigations on the occurrence of hereditary diseases in the Danish cattle population 1989-1991. Acta vet. scand. 1993, 34, 245-253.– The methods of the Danish Bovine Genetic Disease Programme are outlined, and the results obtained during the first 3 years in function are described. The most common disease reported was spinal muscular atrophy in calves of the Red Danish Dairy breed with 312 reports. Necropsy was performed on 162 cases, and spinal muscular atrophy was diagnosed in 82 of these. Bovine progressive degenerative mye-loencephalopathy, rectovaginal constriction, syndrome of arthrogryposis and palatoschisis, hereditary chondrodysplasia (2 different types), syndactylism, epitheliogenesis imperfecta, and osteogenesis imperfecta was diagnosed with 1 case each. Lethal trait A46 was diagnosed in 4 calves. Some of these diseases have not previously been described in Denmark, and epitheliogenesis imperfecta was for the first time diagnosed in the Hereford breed. Chromosome translocation 1/29 was detected in the Blonde d’Aquitaine (BAQ), Limousine, and Red Danish Dairy breed. The aberration occurred frequently in BAQ. Furthermore, a complex chromosome translocation t(l;8;9)(q45;ql3;q26) was detected in the Red Danish Dairy breed.

Keywords: spinal muscular atrophy, weaver syndrome, lethal trait A46, epitheliogenesis imperfecta, rectovaginal constriction, syndactylism, osteogenesis imperfecta, chromosome translocation

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Acknowledgments

We are grateful to the Danish breeding associations, the National Committee on Danish Cattle Husbandry, the Danish Veterinary Service, and to the Department of Radiology and the Division of Large Animal Medicine, the Royal Veterinary and Agricultural University for cooperation. The investigations were supported by a grant from the Danish Research Academy, the National Committee on Danish Cattle Husbandry, and the National Veterinary Laboratory.

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