Abstract
The heritability of calcified intervertebral discs in the dachshund was estimated using data gathered from a radiographic study. Radiographs of the vertebral columns of 274 clinically normal, 12 to 18 months old dachshunds, were examined. The dogs were offspring from 75 different sires, representing the same number of half sib groups. There were 2 to 14 offspring in each half-sib group. The number of full sib groups was 81.
Calcified intervertebral discs were identified in 20.4 % of the dogs. An analysis of variance that used the data as a continuous and as an either/or-variable estimated the heritability of calcified discs to be 0.22 and 0.15 respectively.
A genetic factor was found to be essential for the occurrence of calcified discs in a dog while a common environmental factor presumably resulting from non-genetic causes was significant in determining the number of discs to undergo calcification in affected dogs.
Keywords: vertebral column, degeneration, inheritance, dog
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References
- Andersen S, Andresen, Christensen Hip dyspla–sia selection index exemplified by data from German Shepherd dogs. J. Anim. Breeding and Genetics. 1988;105:112–119. doi: 10.1111/j.1439-0388.1988.tb00280.x. [DOI] [Google Scholar]
- Ball MU, McGuire JA, Swaim SF, Hoerlein BF. Patterns of occurrence of disk disease among registered dachshunds. J. Amer. vet. med. Assoc. 1982;180:519–522. [PubMed] [Google Scholar]
- Brown NO, Helphrey ML, Prata RG. Thoracolum–bar disk disease in the dog: A retrospective analysis of 187 cases. J. Amer. anim. Hosp. Ass. 1977;13:665–672. [Google Scholar]
- Burk RL, Ackerman N. A diagnostic atlas and text. New York: Churchill Livingstone; 1986. Small animal radiology; pp. 341–373. [Google Scholar]
- Falconer DS. Introduction to Quantitative genetics. Harlow: Longman Scientific & Technical; 1989. [Google Scholar]
- Funkquist B, Henricson B. Kann die Frequenz von Bandscheibenprolaps beim Dackel durch eugenische Maßnahmen verhindert werden? (Gene–tical predisposition for disc degeneration in the dachshund) Kleintier-Prax. 1969;14:219–223. [Google Scholar]
- Gage ED. Incidence of clinical disc disease in the dog. J. Amer. anim. Hosp. Assoc. 1975;11:135–138. [Google Scholar]
- Grøndalen J, Lingaas F. Arthrosis in the elbow joint of young rapidly growing dogs: a genetic investigation. J. Small anim. Pract. 1991;32:460–464. doi: 10.1111/j.1748-5827.1991.tb00989.x. [DOI] [Google Scholar]
- Hansen HJ. A pathologic–anatomical study on disc degeneration in dog. Acta orthop. scand. 1952;11:1–117. doi: 10.3109/ort.1952.23.suppl-11.01. [DOI] [PubMed] [Google Scholar]
- Havranek–Balzaretti B. Zürich: Veterinär–Chirurgischen Klinik und Institut für Veterinär–patologie. 1980. Beitrag zur Aetiologie der Dackellähme und Vorschlag zur züchterischen Selektion. (The etiology of intervertebral disc disease in the dachshund and proposal of an eradication programme) [Google Scholar]
- Hedhammar, Wu FM, Krook L, de Schryver HF, Lahunta A, Whalen JP, Kallfelz FA, Nunez EA, Hintz HF, Sheffy BE, Ryan GD. Cornell Vet. 1974. Overnutrition and skeletal disease. An experimental study in growing Great Dane dogs; pp. 1–160. [PubMed] [Google Scholar]
- Lingaas F, Heim En genetisk undersøkelse av hof–teleddsdysplasi i norske hunderaser. (A genetic investigation on hip dysplasia in norwegian dog breeds) Norsk Vetr. Tidsskr. 1987;99:617–623. [Google Scholar]
- Lust G, Farrell PW, Sheffy BE, Van Vleck LD. II. An improved procedure for genetic selection against hip dysplasia in dogs. Cornell Vet. 1978;7:41–47. [PubMed] [Google Scholar]
- Morgan JP, Silverman S. Techniques of veterinary radiography. Ames: Davis: Iowa state university press; 1982. pp. 190–195. [Google Scholar]
- Oliver JE, Hoerlein BF, Meyhew IG. Veterinary neurology. Philadelphia: W. B. Saunders; 1987. pp. 321–341. [Google Scholar]
- Palmer J. The big dog book. Oslo: Teknologisk forlag; 1985. Teknologisk forlags store hundebok; pp. 46–47. [Google Scholar]
- SAS Institute Inc. SAS language guide for personal computers. 1986. pp. 1–429. [Google Scholar]
- Stigen Calcification of intervertebral discs in the dachshund. A radiographic study of 327 young dogs. Acta vet. scand. 1991;32:197–203. doi: 10.1186/BF03546981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Studdert VP, Lavelle RB, Beilharz RG, Mason TA. Clinical features and heritability of osteochon–drosis of the elbow in labrador retrievers. J. Small anim. Pract. 1991;32:557–563. doi: 10.1111/j.1748-5827.1991.tb00885.x. [DOI] [Google Scholar]
- Wallerstedt M. Dachshunds: For hunting, exhibitions, company and breeding. Falköping: Gummes–sons tryckeri AB; 1988. Taxar: Til jakt, utställning, sällskap, avel; pp. 7–189. [Google Scholar]