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. 2021 Apr 14;593(7858):289–293. doi: 10.1038/s41586-021-03460-z

Fig. 2. HP1 binds both A- and B-compartment regions at ZGA.

Fig. 2

a, Hi-C contact map of an 8-Mb region on chromosome 3L (resolution 40 kb). Pooled Hi-C data of seven biological replicates are shown (Extended Data Fig. 2a). b, Compartment scores (first eigenvector of the Hi-C map, resolution: 10 kb), same region as in a (Supplementary Methods). c, Heat maps of HP1, H3K9me3 and H3K9ac ChIP–seq signals as well as repeat positions, ±10 kb centred on HP1 peaks occurring in B-compartment regions. HP1 binding overlaps with broad H3K9me3 peaks, repeats and is devoid of H3K9ac. d, As in c for HP1 peaks in A-compartment regions, showing enrichment in H3K9ac and absence of repeats (Extended Data Fig. 2b–d).