Fig. 3.

Evaluation of CBD (10, 20 and 40 mg/kg) effects on increased anxiety-like behaviour induced by the spontaneous cocaine withdrawal model, in the light-dark box paradigm. Columns represent the means and vertical lines ± SEM of the time spent in the lighted box (s) (A) and the number of transitions (B). *, values from COCA-VEH-treated mice that are significantly different from VEH-VEH-treated mice (one-way ANOVA, P < 0.001). #, values from COCA-CBD-treated groups that are significantly different from COCA-VEH-treated group (one-way ANOVA, P < 0.001). &, values from COCA-CBD (40 mg/kg)-treated group that are significantly different from COCA-CBD (10 and 20 mg/kg) groups (one-way ANOVA, P < 0.05). Number of mice per group n = 9–10