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. 2020 Nov 17;18(1):430–447. doi: 10.1007/s13311-020-00957-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Changes in transcriptional regulators of IL-17A and protein expression of IL-17A. (a) Gene expression of RORγt/BATF/RUNX1. (b) FACS analysis of IL-17A–expressing brain cells. (c, d) Distribution of CD3⁺/CD4⁺/IL-17A triple-stained cells in the brain and spinal cord. Triple-stained cells were counted by particle analysis using ImageJ. (e, f) Distribution of CD3⁺/CD4⁺/GM-CSF triple-stained cells in the brain and spinal cord. The fluorescence intensity of GM-CSF–expressing Th cells in the brain and spinal cord was quantified using ImageJ software. Scale bar indicates 100 μm. Asterisk indicates significant difference compared to control levels (*p < 0.05). Dagger indicates significant difference between experimental groups (^†p < 0.05).