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. 1992 Jun 1;33(2):109–115. doi: 10.1186/BF03547317

Ketamine, Telazol®, Xylazine and Detomidine

A Comparative Anesthetic Drug Combinations Study in Ponies

Ketamin, Telazol, Xylazin och Detomidine: Ett jäm-förande försök mellan fem olika anestetikakombina-tioner hos ponnyn.

H C Lin 1,2,3,✉, K R Branson 1,2,3, J C Thurmon 1,2,3, G J Benson 1,2,3, W J Tranquilli 1,2,3, W A Olson 1,2,3, A T Vähä-Vahe 1,2,3
PMCID: PMC8117853  PMID: 1502994

Abstract

This study was designed to assess the effects of 5 anesthetic drug combinations in ponies: (1) ketamine 2.75 mg/kg, xylazine 1.0 mg/kg (KX), (2) Telazol® 1.65 mg/kg, xylazine 1.0 mg/kg (TX), (3) Telazol® 2 mg/kg, detomidine 20 µg/kg (TD-20), (4) Telazol® 2 mg/kg, detomidine 40 µg/kg (TD-40), (5) Telazol® 3 mg/kg, detomidine 60 µg/kg (TD-60). All drugs were given iv with xylazine or detomidine preceding ketamine or Telazol® by 5 min. Heart rate was decreased significantly from 5 min to arousal after TD-20 but only at 60 and 90 min after TD-40 and TD-60 respectively. Respiratory rate was decreased significantly for all ponies. Induction time did not differ between treatments. Duration of analgesia was 10 min for KX, 22.2 min for TX, 27.5 min for TD-20, 32.5 min for TD-40, and 70 min for TD-60. Arousal time was significantly longer with detomidine and Telazol®. Smoothness of recovery was judged best in ponies receiving KX and TD-40. All ponies stood unassisted 30 min after signs of arousal.

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