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. 2021 Apr 20;10:e61138. doi: 10.7554/eLife.61138

Table 1. The top 25 GO terms associated with DE genes from old vs. old AAV-KL treated mice.

Term P-value Adjusted P-value Odds Ratio Combined Score
regulation of endothelial cell chemotaxis to fibroblast growth factor (GO:2000544) 8.17E-10 1.51332E-08 266.631818 5579.371
sodium ion export from cell (GO:0036376) 7.41E-15 2.92305E-13 149.472477 4863.183
sodium ion export (GO:0071436) 7.41E-15 2.92305E-13 149.472477 4863.183
cGMP biosynthetic process (GO:0006182) 1.79E-21 1.98668E-19 90.9116279 4343.159
cGMP metabolic process (GO:0046068) 1.41E-23 2.15989E-21 82.1943925 4324.53
vascular endothelial growth factor receptor signaling pathway (GO:0048010) 2.24E-39 2.73359E-36 47.4914842 4226.557
cyclic nucleotide biosynthetic process (GO:0009190) 6.81E-18 4.38219E-16 97.8152425 3866.443
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway (GO:0007197) 3.18E-08 4.17609E-07 221.689342 3827.416
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway (GO:0007207) 3.18E-08 4.17609E-07 221.689342 3827.416
calcineurin-NFAT signaling cascade (GO:0033173) 8.94E-12 2.35047E-10 119.031963 3028.225
cellular potassium ion homeostasis (GO:0030007) 8.32E-13 2.71081E-11 100.657895 2799.85
cellular sodium ion homeostasis (GO:0006883) 7.48E-14 2.64978E-12 89.6743119 2710.338
cellular monovalent inorganic cation homeostasis (GO:0030004) 6.58E-15 2.68262E-13 82.3862069 2690.261
cellular response to forskolin (GO:1904322) 3.21E-09 5.4068E-08 133.309091 2607.271
response to forskolin (GO:1904321) 3.21E-09 5.4068E-08 133.309091 2607.271
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 1.92E-67 4.69774E-64 16.4566607 2528.075
ceramide metabolic process (GO:0006672) 4.51E-24 7.3577E-22 45.96 2470.574
regulation of cardiac conduction (GO:1903779) 1.84E-30 4.49925E-28 35.7165215 2445.428
peptidyl-serine dephosphorylation (GO:0070262) 2.96E-10 6.14116E-09 103.915718 2279.845
cyclic purine nucleotide metabolic process (GO:0052652) 3.13E-19 2.38927E-17 51.9335548 2212.838
calcineurin-mediated signaling (GO:0097720) 2.63E-11 6.62923E-10 89.2694064 2174.732
cAMP biosynthetic process (GO:0006171) 2.28E-12 6.89002E-11 80.5221968 2158.455
positive regulation of protein kinase B signaling (GO:0051897) 1.97E-36 1.20529E-33 22.916681 1884.074
regulation of myosin-light-chain-phosphatase activity (GO:0035507) 1.09E-07 1.28925E-06 110.839002 1776.808
cyclic nucleotide metabolic process (GO:0009187) 1.16E-15 5.76736E-14 48.8926097 1681.61