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. 2021 Apr 19;11(13):6334–6354. doi: 10.7150/thno.59342

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(A) Schematic illustration of the redox-responsive SO₂-releasing nanosystem for producing synergistic effect of chemotherapy and gas therapy. (B) Mechanism of the reversal of MDR by the released SO₂ and combination therapy. Reproduced with permission from Ref. 149, Copyright © 2020, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. (C) Schematic illustration of the in situ photo-activated H₂ nanogenerator ([FeFe]TPP/GEM/FCS) for enhanced chemotherapy of bladder cancer. (D) Mechanism of the recovery of chemosensitivity by H₂ suppressing P-gp pump. Reproduced with permission from Ref. 107, Copyright © 2020, American Chemical Society. Abbreviations: MON: mesoporous organosilica nanoparticle; PCBMA: poly(carboxybetaine methacrylate); GEM: gemcitabine; FCS: fluorinated chitosan.