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. 2021 Apr 19;11(13):6334–6354. doi: 10.7150/thno.59342

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(A) The formation of DOX+HCPT-M micelles via the self-assembly of DOX-conjugated polymer with free HCPT. (B) Schematic illustration of co-delivery of a π-π stacked combination of DOX and HCPT using an intelligent micellar platform for overcoming breast cancer MDR. Reproduced with permission from Ref. 27, Copyright © 2016, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. (C) Schematic illustration of the preparation, surface modification, dual-drug loading and drug releasing of the designed polymeric nanogels. (D) In vivo antitumor activity evaluation of different therapeutic formulations in BALB/c nude mice bearing MCF-7/ADR tumors. Reproduced with permission from Ref. 48, Copyright © 2017, American Chemical Society. Abbreviations: P-gp: P-glycoprotein; BCRP: breast cancer resistance protein; DOX: doxorubicin; HCPT: 10-hydroxycamptothecin; CDDP: cisplatin; FA: folate.