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. 2021 Apr 19;11(13):6334–6354. doi: 10.7150/thno.59342

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(A) Disclosure of the reversal mechanism of MDR via DOX-loaded micelles (HPHM/TPGS2000). After HPHM/TPGS2000 were selectively uptook by MCF-7/ADR cells via CD44 receptor-mediated endocytosis, pH-triggered release of TPGS2000 could suppress P-gp efflux pump to restore the chemosensitivity of DOX. Reproduced with permission from Ref. 77, Copyright © 2014, Elsevier. (B) The preparation and mechanism of mitochondria-targeted pH-responsive PDPA/TPGS@DOX micelles to overcome DOX resistance in breast cancer cells. Reproduced with permission from Ref. 131, Copyright © 2015, Elsevier. (C) Schematic design of multifunctional liposomes for co-delivery of TPGS and chemotherapeutics to reverse MDR in cancer treatment. Reproduced with permission from Ref. 133, Copyright © 2015, Elsevier. Abbreviations: TPGS: D-α-tocopheryl polyethylene glycol 1000 succinate; HA: hyaluronic acid; HG2C₁₈: 1,5-dioctadecyl-N-histidyl-_L-glutamate; LND: lonidamine; PTX: paclitaxel.