Corrigendum to “Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway” [Bioact. Mater. 5 (2020) 334–347]

The authors regret that the printed version of the above article contained a number of errors which were not identified during the proofing stage. The correct and final version follows. The authors would like to apologies for any inconvenience caused.

The authors regret:

1. “…and the underlying molecular mechanism of this simulation is yet to be determined”, Page 335, needs to be corrected to “and the underlying molecular mechanism of this stimulation is yet to be determined”.

2. A flaw was spotted in Figure 7 after careful examining of the printing version. A part of Fig. 7c seemed to be duplicated and presented in Fig. 7d. The authors had also checked the original images and found Fig. 7c and d were taken from the same sample of 6Sr with continuous imaging, but with wrong labeling in group d. By considering scientific rigor, the authors also repeated the ALP staining experiments of Fig. 7a–f recently. The results of repeated ALP staining are consistent with those of previous experiments.

Fig. 7. Optical micrographs of (a) BG, (b) BG3Sr, (c) BG6Sr, (d) BG9Sr and (e) BG12Sr cement stained with Alizarin red S; (f) mineralized nodule formed by hBMSCs in extracts of culture media at 21 days of culture. (Mean ± SD; n = 5; *significant difference compared with the BG group, p < 0.05; # significant difference between groups, p < 0.05).

3. After carefully re-examined the origin data, it was found that “Wnt3A” was written into “Wnt5A” mistakenly, and the authors deeply regretted the careless. As a matter of fact, “Wnt5A” isn't included in the genes of Wnt/β-catenin signaling pathway (classical Wnt pathway). Therefore, all of the “Wnt5A” was revised to “Wnt3A”, including in Fig. 9a and b. Also, after carefully re-examined, it was found that “DKK1” was written into “DDK1” mistakenly in Fig 9b, and the authors deeply regretted the careless. Therefore, “DDK1” in Fig 9b was revised to “DKK1”.

Fig. 9. (a) Wnt/β-Catenin signaling pathways related genes expression of hBMSCs cultured with borosilicate glass cements for 7 days; and (b) the same related genes expression of hBMSCs cultured with borosilicate glass cements for 7 days with FH 535 pretreated; (c) β-Catenin protein expression of hBMSCs cultured with borosilicate glass cements supplemented with osteogenic medium for 14 days by western blot analysis; and (d) semi-quantitative statistical analysis of the gray-scale value of the straps. (Mean ± SD; n = 5; *significant difference compared with the control group, p < 0.05; # significant difference between groups, p < 0.05).

The authors apologize for all these errors and state that these corrections do not change the scientific conclusions of the article in any way.