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. 2021 Apr 21;26(9):2422. doi: 10.3390/molecules26092422

Figure 4.

Figure 4

Pan-caspase inhibitor Z-VAD-FMK does not prevent garcinielliptone G (5)-induced apoptosis. (a) THP-1 and (b) Jurkat cells were treated with Z-VAD-FMK (50 µM) 1 h before garcinielliptone G (5) addition, and cell viability was determined by the WST-1 assay. (c) and (d) THP-1 cells were treated with inhibitors Z-VAD-FMK (50 µM), necrostatin-1 (10 µM), and ferrostatin-1 (1 µM) 1 h prior to the addition of garcinielliptone G (5). These inhibitors did not prevent apoptosis caused by garcinielliptone G (5). Values are presented as the mean ± SD of three independent experiments. * p < 0.05, ** p < 0.01.