Fig. 1. Rapid spread of VOC 202012/01 in England.
(A) Proportion of S gene target failure among positive Pillar 2 community SARS-CoV-2 tests in upper-tier local authorities of England from 1 October 2020 to 10 January 2021, sorted by latitude. (B) Spread of S gene target failure by age, index of multiple deprivation decile (1 = most deprived), and sex within Greater London. (C and D) Estimates of R0 from CoMix social contact survey (12) compared to Rt estimates from REACT-1 prevalence survey (9) for England, with 90% CIs. Rt estimates based on single and aggregated REACT-1 survey rounds are shown. Horizontal error bars in (C) show the date range over which Rt was measured. (E and F) Percentage change (95% CI) in Google Mobility indices relative to baseline over time (E) and setting-specific mean contacts (95% CI) from the CoMix study (12) over time and by age for Tier 4 local authorities compared to the rest of England (F). Tier 4 local authorities are areas within the South East, East of England, and London regions that were placed under stringent restrictions from 20 December 2020 because of high prevalence of VOC 202012/01 and growing case rates. Gray shaded areas show the second national lockdown in England.