Exosomes released by human umbilical cord mesenchymal stem cells protect against renal interstitial fibrosis through ROS-mediated P38MAPK/ERK signaling pathway

During the final submission of high-resolution figures for this manuscript’s publication, the images in Figure 6Aj were inadvertently replaced with images from published Figure 6Aj. The published version of Figure 6Aj is therefore incorrect. The corrected version of the figure, as originally submitted and reviewed in all versions before the last, is shown below. The only change is in the panels of Figure 6Aj; the rest of the figure is identical to the published version. All of he published results and conclusions of the paper remain unchanged. We apologize for this oversight and for any confusion that it has caused.

Figure 6.

The effect of hucMSC-Ex on the histopathology and function of UUO-induced kidneys. (A) Histopathology analysis of the kidney in each group. (a-d) H&E staining, (e-h) PAS staining, (i-l) Masson’s trichrome staining. (B) Tubular damage was scored by calculation of the percentage of tubules that displayed cell necrosis, loss of the brush border, cast formation, and tubular dilatation. (C) Area of renal interstitial fibrosis in each group. (D, E) BUN and Scr values in each group at 0, 3, 7, 14 days. Values presented as mean ± SD. *P<0.05 versus UUO group; #P<0.05 versus sham and control group. BUN blood urea nitrogen, Ex exosome, HE hematoxylin-eosin, hucMSC human umbilical cord-derived mesenchymal stem cell, PAS periodic acid schiff, Scr serum creatinine, UUO unilateral ureteral obstruction.