The original version of the article published with errors in Table 2. For clarity, the corrected version of this table is shown below
Table 2.
Experimental studies on the infective dose of coronaviruses in various mammals
| Virus | Host | Dose (PFU) | Route of inoculation | Numbers and/or %, signs of infection | References | 
|---|---|---|---|---|---|
| SARS-CoV-2 | aFerret | 221 359 | IN | 6/6 | Kim [16] | 
| 500 | IN | 16.7,1/6 | Ryan [17] | ||
| 50 000 | IN | 6/6 | |||
| 5 000 000 | IN | 6/6 | |||
| 420 000 | IN | 4/4 | Richard [18] | ||
| SARS-CoV-2 HCoV-OC43 | bhACE2 mice | 70 000 | IN | 36.8,7/19 | Bao [19] | 
| 400 000 | IN | 3/3 | Sun [20] | ||
| 4 000 000 | IG | 1/3 | |||
| 630 | Aerosol | 2/2 | Bao [21] | ||
| 21 000 | IN | 50% Lethal | Jiang [22] | ||
| 100 000 | IN | 40% Lethal | Dinnon [23] | ||
| BALB/c mice | 16 000 | IN | 3/3 | Gu [24] | |
| BALB/c and C57B6 mice | 70 000 | IP/IC | 100% Lethal | Jacomy [25] | |
| BALB/c mice | 70 | IC | 100% Lethal | Shen [26] | |
| SARS-CoV-1 | tgMice | 280 | IN | NR | Watanabe [8] | 
| MERS-CoV | tgMice | 0.7 | IN | NR | Tao [27] | 
| 7 | IN | 50% Lethal | |||
| SARS-CoV-2 | cCynomolgus macaques | 48 600 | Aerosol | 4/4 | Johnston [28] | 
| 700 000 | IN/IT | 4/4 | Rockx [29] | ||
| SARS-CoV-2 | dRhesus macaques | 700 000 | IO | 2/2 | Deng [30] | 
| IT | 1/1 | ||||
| IG | 0/2 | ||||
| 1 820 000 | IN/IT/IO/Oral | 8/8 | Munster [31] | ||
| 11 000 | IN/IT | 3/3 | Chandrashekar [32] | ||
| 110 000 | IN/IT | 3/3 | |||
| 1 100 000 | IN/IT | 3/3 | |||
| 28 700 | Aerosol | 4/4 | Johanston [28] | ||
| SARS-CoV-2 | eAfrican green monkeys | 38 000 | Aerosol | 3/3 | Johanston [28] | 
| 500 000 | IN/IT | 6/6 | Woolsey [33] | ||
| 3 000 000 | IN | 6/6 | Cross [34] | ||
| 2000 | Aerosol | 2/2 | Blair [35] | ||
| 3 610 000 | IO/IT/IN/Oral | 2/2 | |||
| SARS-CoV-2 | fSyrian hamster | 398 107 | IN/IO | 4/4 | Imai [36] | 
| 1000 | IN/IO | 4/4 | |||
| 56 000 | IN | 3/3 | Sia [37] | ||
| 100 000 | IN | 75,24/36 | Osterrieder [38] | ||
| Immunocompromised syrian hamster | 100 | IN | 10/10 | Brocato [39] | |
| 1000 | IN | ||||
| 10 000 | IN | 40% Lethal | |||
| gBats | 70 000 | IN | 78,7/9 | Schlottau [40] | 
TCID50, %50 tissue infective culture dose; PFU, plaque-forming units; tgMice, transgenic mice; hACE2, human angiotensin converting enzyme 2, BALB/c; begg albino laboratory-bred mouse, IN; intranasal, IG; intragastric, IO; intraocular, IT; intrathecal, IC; intracerebral, IP; intraperitoneal, NR; not reported.
One of the authors’ names was also formatted incorrectly. The correct name is Nguyen Tien Huy. This has now been updated in the original article.
Reference
- Karimzadeh, S., Bhopal, R., & Nguyen Tien, H. (2021). Review of infective dose, routes of transmission and outcome of COVID-19 caused by the SARS-COV-2: Comparison with other respiratory viruses. Epidemiology and Infection, 149, E96. doi: 10.1017/S0950268821000790 [DOI] [PMC free article] [PubMed] [Google Scholar]
