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. 2021 May 14;149:e116. doi: 10.1017/S0950268821001084

Review of infective dose, routes of transmission and outcome of COVID-19 caused by the SARS-COV-2: comparison with other respiratory viruses– CORRIGENDUM

Sedighe Karimzadeh 1, Raj Bhopal 2, Huy Nguyen Tien 3
PMCID: PMC8129670  PMID: 33985614

The original version of the article published with errors in Table 2. For clarity, the corrected version of this table is shown below

Table 2.

Experimental studies on the infective dose of coronaviruses in various mammals

Virus Host Dose (PFU) Route of inoculation Numbers and/or %, signs of infection References
SARS-CoV-2 aFerret 221 359 IN 6/6 Kim [16]
500 IN 16.7,1/6 Ryan [17]
50 000 IN 6/6
5 000 000 IN 6/6
420 000 IN 4/4 Richard [18]
SARS-CoV-2 HCoV-OC43 bhACE2 mice 70 000 IN 36.8,7/19 Bao [19]
400 000 IN 3/3 Sun [20]
4 000 000 IG 1/3
630 Aerosol 2/2 Bao [21]
21 000 IN 50% Lethal Jiang [22]
100 000 IN 40% Lethal Dinnon [23]
BALB/c mice 16 000 IN 3/3 Gu [24]
BALB/c and C57B6 mice 70 000 IP/IC 100% Lethal Jacomy [25]
BALB/c mice 70 IC 100% Lethal Shen [26]
SARS-CoV-1 tgMice 280 IN NR Watanabe [8]
MERS-CoV tgMice 0.7 IN NR Tao [27]
7 IN 50% Lethal
SARS-CoV-2 cCynomolgus macaques 48 600 Aerosol 4/4 Johnston [28]
700 000 IN/IT 4/4 Rockx [29]
SARS-CoV-2 dRhesus macaques 700 000 IO 2/2 Deng [30]
IT 1/1
IG 0/2
1 820 000 IN/IT/IO/Oral 8/8 Munster [31]
11 000 IN/IT 3/3 Chandrashekar [32]
110 000 IN/IT 3/3
1 100 000 IN/IT 3/3
28 700 Aerosol 4/4 Johanston [28]
SARS-CoV-2 eAfrican green monkeys 38 000 Aerosol 3/3 Johanston [28]
500 000 IN/IT 6/6 Woolsey [33]
3 000 000 IN 6/6 Cross [34]
2000 Aerosol 2/2 Blair [35]
3 610 000 IO/IT/IN/Oral 2/2
SARS-CoV-2 fSyrian hamster 398 107 IN/IO 4/4 Imai [36]
1000 IN/IO 4/4
56 000 IN 3/3 Sia [37]
100 000 IN 75,24/36 Osterrieder [38]
Immunocompromised syrian hamster 100 IN 10/10 Brocato [39]
1000 IN
10 000 IN 40% Lethal
gBats 70 000 IN 78,7/9 Schlottau [40]

TCID50, %50 tissue infective culture dose; PFU, plaque-forming units; tgMice, transgenic mice; hACE2, human angiotensin converting enzyme 2, BALB/c; begg albino laboratory-bred mouse, IN; intranasal, IG; intragastric, IO; intraocular, IT; intrathecal, IC; intracerebral, IP; intraperitoneal, NR; not reported.

One of the authors’ names was also formatted incorrectly. The correct name is Nguyen Tien Huy. This has now been updated in the original article.

Reference

  1. Karimzadeh, S., Bhopal, R., & Nguyen Tien, H. (2021). Review of infective dose, routes of transmission and outcome of COVID-19 caused by the SARS-COV-2: Comparison with other respiratory viruses. Epidemiology and Infection, 149, E96. doi: 10.1017/S0950268821000790 [DOI] [PMC free article] [PubMed] [Google Scholar]

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