Table 3.

Diagnostic performance of OFR and OCT-derived MLA.

	OFR ≤0.80	MLA ≤1.89
Accuracy, % (95% CI)	90 (84–95)	74 (67–82)
Sensitivity, % (95% CI)	87 (77–94)	78 (66–87)
Specificity, % (95% CI)	92 (82–97)	71 (58–82)
PPV, % (95% CI)	92 (82–97)	73 (61–83)
NPV, % (95% CI)	88 (77–95)	76 (63–86)
LR+ (95% CI)	10.8 (4.6–25.2)	2.7 (1.8–4.0)
LR− (95% CI)	0.1 (0.1–0.3)	0.3 (0.2–0.5)

The diagnostic accuracy was defined as the classification concordance between OFR evaluated outcomes (≤0.8 or >0.8) and FFR evaluated outcomes (≤0.8 or >0.8). Sensitivity was defined as the proportion of OFR ≤0.8 or MLA ≤1.89 mm² by OCT in vessels with haemodynamically significant stenosis; specificity was defined as the proportion of QFR >0.8 or MLA >1.89 mm² by OCT in vessels without haemodynamically significant stenosis. CI: confidence interval; FFR: fractional flow reserve; LR−: negative likelihood ratio; LR+: positive likelihood ratio; MLA: minimum lumen area; NPV: negative predictive value; OCT: optical coherence tomography; OFR: optical coherence tomography-based fractional flow reserve; PPV: positive predictive value