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. 1990 Mar 1;31(1):27–38. doi: 10.1186/BF03547574

Investigation of the Possible Role of Endotoxin, TXA2, PGI2 and PGE2 in Experimentally Induced Rumen Acidosis in Cattle

Undersøgelse af endotoksin, TXA2, PGI2 og PGE2 ved eksperimentelt induceret vomacidose hos kvæg

P Haubro Andersen 1,✉, N Jarløv 1
PMCID: PMC8133123  PMID: 2119094

Abstract

Haubro Andersen, P. and N. Jarløv: Investigation of the possible role of endotoxin, TXA2, PGI2 and PGE2 in experimentally induced rumen acidosis in cattle. Acta vet. scand. 1990, 31, 27–38. - Rumen acidosis was induced experimentally with 70 g barley/kg b.w. in 2 rumen fistulated cows. The cows were followed for 80 h after the grain engorgement. Endotoxin was monitored in cell-free ruminai fluid and peripheral plasma together with inflammation mediators TXA2, PGI2 and PGE2 and several clinical and clinical-chemical parameters. The results do not support the theory of systemical endotoxemia due to a large increase in rumen endotoxin concentration in cattle suffering from rumen acidosis. However, both clinical and clinical-chemical data suggest that an endotoxicosis developed, but the levels of inflammation mediators TXB2, FGI2 and PGE2 were not significantly elevated in the peripheral circulation. An absorbtion of endotoxins and synthesis of inflammation mediators are therefore suggested to take place prehepatically.

Keyword: Limulus amoebocyte lysate test; hypozincaemia; Cortisol, stress-response; rumen endotoxin

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