Fig. 2. Blockade of D₁ vs D₂ receptors within mOFC differentially alters probabilistic reversal learning.

A Infusion of SCH 23390 into the mOFC (n = 13) reduced the number of reversals completed. B Errors to achieve criterion performance during the initial discrimination and first reversal phases. D₁ blockade increased errors made during the initial discrimination and following the first reversal. C D₁ blockade increased lose–shift behavior during the initial discrimination but did not affect win–stay or lose–shift ratios following the first reversal. D Infusion of eticlopride into the mOFC (n = 15) increased the number of reversals completed. E D₂ blockade reduced errors during the initial discrimination and first reversal phases. F D₂ blockade reduced lose–shift behavior during the initial discrimination of the task. For this and all other figures, error bars are SEM, stars denotes p < 0.05 compared to saline and brackets above the bars in B and E indicate significant main effect of treatment independent of phase.