Fig. 4. Blockade of D₁ and D₂ receptors within the mOFC differentially impairs probabilistic discounting.

A Percentage choice of the large/risky option following infusion of SCH 23390 into the mOFC (n = 14) across five blocks of free-choice trials. Inset displays the main effect in the analysis, averaging total percentage of large/risky choice across the all trial blocks. Blockade of D₁ receptors reduced choice for the larger reward. B Win–stay/lose–shift ratios. D₁ blockade at the high dose increased sensitivity to losses and to a lesser degree, wins. C Percentage choice of the large/risky option following infusion of eticlopride into the mOFC (n = 12) across five blocks of free-choice trials. Inset displays large/risky choice averaged across the all block of trials demonstrating the main effect of treatment and increase in risky choice. D Win–stay/lose–shift ratios following intra-mOFC eticlopride.