Brett A Eyford
Brett A Eyford
1Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
2The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
3Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
4The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada
1,2,3,4,†,
Chaahat S B Singh
Chaahat S B Singh
1Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
2The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
3Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
4The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada
5Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
1,2,3,4,5,†,
Thomas Abraham
Thomas Abraham
6Department of Neural and Behavioral Sciences and Microscopy Imaging Core Lab, Pennsylvania State College of Medicine, Hershey, PA, United States
6,†,
Lonna Munro
Lonna Munro
1Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
3Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
1,3,
Kyung Bok Choi
Kyung Bok Choi
1Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
3Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
1,3,
Tracy Hill
Tracy Hill
7Centre for Comparative Medicine, University of British Columbia, Vancouver, BC, Canada
7,
Rhonda Hildebrandt
Rhonda Hildebrandt
7Centre for Comparative Medicine, University of British Columbia, Vancouver, BC, Canada
7,
Ian Welch
Ian Welch
7Centre for Comparative Medicine, University of British Columbia, Vancouver, BC, Canada
7,
Timothy Z Vitalis
Timothy Z Vitalis
8Department of Chemistry, University of British Columbia, Vancouver, BC, Canada
9Bioasis Technologies Inc., Guilford, CT, United States
8,9,
Reinhard Gabathuler
Reinhard Gabathuler
9Bioasis Technologies Inc., Guilford, CT, United States
10King's College London, London, United Kingdom
9,10,
Jacob A Gordon
Jacob A Gordon
2The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
11Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
2,11,
Hans Adomat
Hans Adomat
2The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
11Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
2,11,
Emma ST Guns
Emma ST Guns
2The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
11Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
2,11,
Chieh-Ju Lu
Chieh-Ju Lu
1Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
2The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
3Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
4The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada
1,2,3,4,
Cheryl G Pfeifer
Cheryl G Pfeifer
1Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
2The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
3Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
4The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada
1,2,3,4,
Mei Mei Tian
Mei Mei Tian
9Bioasis Technologies Inc., Guilford, CT, United States
9,
Wilfred A Jefferies
Wilfred A Jefferies
1Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
2The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
3Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
4The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada
5Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
11Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
12Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
13Department of Zoology, University of British Columbia, Vancouver, BC, Canada
1,2,3,4,5,11,12,13,*
1Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada
2The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
3Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada
4The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada
5Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
6Department of Neural and Behavioral Sciences and Microscopy Imaging Core Lab, Pennsylvania State College of Medicine, Hershey, PA, United States
7Centre for Comparative Medicine, University of British Columbia, Vancouver, BC, Canada
8Department of Chemistry, University of British Columbia, Vancouver, BC, Canada
9Bioasis Technologies Inc., Guilford, CT, United States
10King's College London, London, United Kingdom
11Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
12Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
13Department of Zoology, University of British Columbia, Vancouver, BC, Canada
Approved by: Frontiers Editorial Office, Frontiers Media SA, Switzerland
✉*Correspondence: Wilfred A. Jefferies wilf@msl.ubc.ca
This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences
†These authors have contributed equally to this work and share first authorship
Received 2021 Mar 29; Accepted 2021 Mar 30; Collection date 2021.
Keywords: stroke, peptide-oligonucleotide conjugate, MTfp, blood-brain barrier, NOX4, siRNA
Copyright © 2021 Eyford, Singh, Abraham, Munro, Choi, Hill, Hildebrandt, Welch, Vitalis, Gabathuler, Gordon, Adomat, Guns, Lu, Pfeifer, Tian and Jefferies.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.