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m6A modification determines RNA life fate. Shown here is the working model of methyltransferase complex, demethylases, and m6A binding proteins. A, adenosine; m6A, N6-methyladenosine; m6Am, N6, 2’-O-dimethyladenosine; Am, 2’-O-methyladenosine; snRNA, small nuclear RNA; m7G, N7-methylguanosine; AAA(n), polyadenylation.
