Figure 2.

Enhanced ACE2 binding to spike protein by anti-NTD antibodies

(A) ACE2-Fc binding to the spike transfectants in the various concentrations of antibodies.

(B) ACE2-Fc binding to the wild-type or D614G spike protein in the presence of 3 μg/mL COV2-2490 monoclonal antibody (mAb). The statistical significance derived from an unpaired t test is indicated.

(C) ACE2-Fc binding to wild-type spike protein in the presence of the indicated antibodies at 3 μg/mL and various concentrations of anti-RBD neutralizing antibody C144 (red line). ACE2-Fc binding in the absence of the enhancing antibodies was shown as the control (black line). The data from triplicates are presented as mean ± SD. Representative data from three independent experiments are shown.

See also Figure S2.