Figure 7.

A suggested mechanism by which β-ionone attenuates glucocorticoid-induced suppression of collagen and hyaluronic acid synthesis in human dermal fibroblasts. As shown in a schematic illustration, the inhibition of glucocorticoid binding to its receptor by β-ionone suppresses the glucocorticoid-induced GR signaling and subsequent collagen and hyaluronic acid degradation. The detailed molecular mechanism of how GR transcription factor regulates collagen and hyaluronic acid needs further investigation.