Table 1.

Descriptions of the published cases of neuroinvasive disease in humans caused by astroviruses.

Astrovirus Genotype	Patient Age	Sex	Location	Past Medical History	Positive Assay(s)	Astrovirus Positive Specimens	Outcome	Year of Publication	Reference
VA1	8 mos	Female	UK	Hematopoietic stem cell transplant	NGS/PCR	Brain	Death	2016	[91]
VA1	18 mos	Male	UK	Hematopoietic stem cell transplant	NGS/PCR/IHC	Brain, CSF, stool, serum	Death	2015	[88]
VA1	14 yrs	Male	France	X-linked agammaglobulinemia	NGS/PCR	Brain	Recovery	2015	[90]
VA1	15 yrs	Male	USA	X-linked agammaglobulinemia	NGS/PCR/IHC	Brain	Death	2010	[84]
VA1	42 yrs	Male	UK	Hematopoietic stem cell transplant	NGS/PCR/ISH	Brain/CSF	Death	2015	[89]
MLB1	4 yrs	Male	Japan	Hematopoietic stem cell transplant	NGS/PCR	CSF, serum, stool, urine, oropharyngeal swab	Recovery	2016	[92]
MLB2	21 yrs	Female	Switzerland	Previously healthy	NGS/PCR	CSF, stool, urine, plasma	Recovery	2016	[83]
MLB2	29 yrs	Female	USA	Previously healthy	NGS	CSF	Recovery	2019	[93]
MLB2	37 yrs	Male	Switzerland	Hematopoietic stem cell transplant	PCR	CSF, stool, plasma	Death	2016	[83]
Human astrovirus serotype 1	16 mos	Female	Germany	Previously healthy	PCR	CSF	Recovery	2019	[94]
Human astrovirus serotype 4	3 mos	Male	Switzerland	Hematopoietic stem cell transplant	PCR	Brain, plasma, skin, heart, lung, spleen, bone marrow, kidney, stool, small intestine	Death	2011	[19]