Table 4.
RC-NF | HC-NF | RC-HF | HC-HF | P GD | P PWD | P GD*PWD | |
---|---|---|---|---|---|---|---|
C 16:1 n-7/C16:0 | 0.08 ± 0.008 | 0.13 ± 0.013* | 0.049 ± 0.006 | 0.037 ± 0.003 | 0.07 | 0.01 | 0.01 |
C18:1 n-9/C18:0 | 0.73 ± 0.07 | 0.84 ± 0.09 | 1.63 ± 0.24 | 0.98 ± 0.15 * | 0.09 | 0.01 | 0.02 |
DHA/ARA | 0.36 ± 0.02 | 0.36 ± 0.02 | 1.19 ± 0.12 | 1.69 ± 0.06 * | 0.36 | 0.33 | 0.21 |
DHA/EPA | 22.5 ± 3.5 | 21.9 ± 1.8 | 20.4 ± 2.5 | 33.7 ± 6.55 | 0.12 | 0.24 | 0.11 |
n-6/n-3 | 4.28 ± 0.21 | 4.23 ± 0.22 | 5.43 ± 0.21 | 4.52 ± 0.23 ** | 0.03 | 0.01 | 0.05 |
1 Male Wistar offspring were born to dams fed either a recommended choline (RC) or a high choline (HC) gestational diet (GD) then weaned to either a normal fat (NF) or high fat (HF) post-weaning diet (PWD) for 17 weeks. Values are mean ± SEM, n = 8–9/group. Data were analyzed using a 2-way ANOVA to test the interaction effect of GD and PWD. * p < 0.05, ** p < 0.01 by Student’s T-test comparing groups stratified by PWD. Abbreviations: RC-NF: recommended choline (1 g/kg) gestational diet weaned to normal fat (16%Kcal) post-weaning diet; HC-NF: high choline (2.5 g/kg) gestational diet weaned to normal fat (16% Kcal) post-weaning diet; RC-HF: recommended choline (1 g/kg) gestational diet weaned to high fat (45%Kcal) post-weaning diet; HC-HF: high choline (2.5 g/kg) gestational diet weaned to high fat (45%Kcal) post-weaning diet; DHA: docosahexaenoic acid; ARA: arachidonic acid; EPA: eicosapentaenoic acid; n-6: omega-6 polyunsaturated fatty acids; n-3: omega-3 polyunsaturated fatty acids.