Table 2.
Molecules affected by the SNARE proteins in the pathophysiology of neurodegenerative diseases.
| Neurodegenerative Disease | Molecule Affected | Function |
|---|---|---|
| AD | Aβ | Aβ accumulation, secretion, plaque formation |
| AD | Tau | Cytoplasmic transport, NFTs |
| AD | Munc 18-1 | Regulation of SNARE complex formation, exocytosis and neurotransmission |
| AD | presenilin 1 | Regulation of Aβ production |
| PD | α-synuclein | Synaptic modulatory protein |
| PD | LRRK2 | Synaptic vesicle fusion |
| PD | NSF | Regulation of SNARE complex disassembly |
| ALS | SOD1 | Superoxide dismutase |