Table 1.
Role beyond cancers: involvement of TRIMs in multiple non-cancerous disorders.
| Therapeutic Area | Disease | TRIM | PMID |
|---|---|---|---|
| Cardiovascular and metabolic diseases | Hypertrophic cardiomyopathy (HCM) | TRIM63 | PMID: 32451364 |
| Cardiac hypertrophy | TRIM8 | PMID: 27956576 | |
| TRIM32 | PMID: 26884348 | ||
| Cardiomyopathy | TRIM76 (CMYA5) | PMID: 18344630 | |
| Diabetic cardiomyopathy, cardiac I/R Injury | TRIM72 (MG53) | PMID: 28432201 | |
| Neurological, neurodegenerative, and neuropsychiatric diseases | Schizophrenia | TRIM76 (CMYA5) | PMID: 20838396 |
| TRIM1 (MID2) | PMID: 24115387 | ||
| TRIM19 (PML) | PMID: 21822266 | ||
| Alzheimer’s disease | TRIM20 | PMID: 17090974 | |
| Parkinson’s disease | TRIM8 | PMID: 32463919 | |
| TRIM32 | PMID: 28508149 | ||
| TRIM10 | PMID: 28586827 | ||
| Epilepsy | TRIM8 | PMID: 30244534 | |
| TRIM27 | PMID: 33385414 | ||
| Multiple sclerosis (MS) | TRIM5 | PMID: 21311761 | |
| TRIM10 | PMID: 28586827 | ||
| HTLV-1-Associated Myelopathy (HAM/TSP) | TRIM22 | PMID: 29872426 | |
| TRIM5 | PMID: 29872426 | ||
| Developmental diseases | Limb-girdle muscular dystrophy 2H | TRIM32 | PMID: 21496629 |
| Mulibrey nanism (MUL) | TRIM37 | PMID: 27044324 | |
| Williams-Beuren syndrome (WBS) | TRIM50 | PMID: 18398435 | |
| Muscle weakness | Thyrotoxic periodic paralysis (TPP) | TRIM2 | PMID: 33105104 |
| Autoimmune disease | Celiac disease | TRIM10 | PMID: 28586827 |