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. 2021 Apr 28;11(5):650. doi: 10.3390/biom11050650

Figure 4.

Figure 4

The influence of rapamycin pre-treatment (3 and 10 mg/kg, i.p.) during neonatal period before every ethanol administration (PND4–9) on the reversal learning impairments in adult (PND67–69) male and female rats in the Barnes maze task. Primary latency (A,C) and number of errors (B,D) are expressed as mean ± SEM of 8 subjects per group (R 3.6.0. for Windows). * p < 0.05; ** p < 0.01; *** p < 0.001 vs. SI; ^ p < 0.05; ^^ p < 0.01; ^^^ p < 0.001 vs. EtOH. R3–rapamycin 3 mg/kg; R10–rapamycin 10 mg/kg, SI–shame intubation (i.g.); EtOH–ethanol intubation (i.g.).