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. 2021 Apr 28;11(5):650. doi: 10.3390/biom11050650

Figure 6.

Figure 6

The influence of rapamycin pre-treatment (3 and 10 mg/kg, i.p.) during neonatal period before every ethanol administration (PND4–9) on the expression of GluN2B subunit of NMDA receptor in adult (PND69) male and female rats in the prefrontal cortex (A,C) and hippocampus (B,D). Striatum: (E,F). Results are expressed as mean ± SEM of 8 subjects per group. ** p < 0.01; *** p < 0.001 vs. SI; ^ p < 0.05; ^^ p < 0.01; ^^^ p < 0.001 vs. EtOH. NS–nonsignificant vs. the non-alcohol treated controls; EtOH R3–rapamycin 3 mg/kg; R10–rapamycin 10 mg/kg, SI–shame intubation (i.g.); EtOH–ethanol intubation (i.g.).