Figure 4.

Pathway enrichment analysis of genes identified in lncRNA-mRNA co-expression networks. Two main clusters of mRNA were found to be associated (Pearson’s correlation coefficient, p-value < 0.05, −0.8 < R > 0.8) to lncRNA expression. The genes in cluster #1, left panel, were predominantly involved in biological processes related to cellular response to chemical, xenobiotics, or drug stimulus. Cluster #3, with 4 times more genes (right panel), was highly enriched for genes that control the cell cycle, chromosomal organization, and DNA damage/repair response.