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Frontiers in Oncology logoLink to Frontiers in Oncology
. 2021 May 11;11:693855. doi: 10.3389/fonc.2021.693855

Corrigendum: E3 Ubiquitin Ligase UBR5 Promotes the Metastasis of Pancreatic Cancer via Destabilizing F-Actin Capping Protein CAPZA1

Jin Li 1,, Wei Zhang 1,, Jian Gao 1, Min Du 1, Huimin Li 1, Mengge Li 1,2, Hui Cong 1, Yuan Fang 3, Yiyi Liang 1, Dan Zhao 1, Gang Xiang 4, Xiaojing Ma 4, Ming Yao 1, Hong Tu 1,*, Yu Gan 1,*
PMCID: PMC8147866  PMID: 34046366

In the original article, there were two mistakes in Figure 2 as published. In Figure 2D, the image for 0h shNC group was same as the image for 0h shUBR5-1 group in the wound healing experiment of PANC-1 cells. In Figure 2E, the cell line names above the bar graph (right panel) were incorrectly given as “CFPAC-1” and “BxPC-3”. They should be “CFPAC-1” and “PANC-1”, consistent with the cell line names given in the left panel. The corrected Figure 2 appears below.

Figure 2.

Figure 2

UBR5 promotes pancreatic cancer migration and invasion in vitro. (A) Relative mRNA expression and (B) protein levels of UBR5 in various pancreatic cancer cells and normal pancreatic cells measured by quantitative real-time PCR and western blot separately. The histogram shows the densitometric analysis of the bands. (C) The protein levels of UBR5 in CFPAC-1 and PANC-1 cells after infection with shNC or shUBR5. The histogram shows the densitometric analysis of the bands. (D, E) Wound healing and invasion assays in CFPAC-1 and PANC-1 cells infected with shNC or shUBR5. (F) The UBR5 protein levels in MIA PaCa-2 and BxPC-3 transiently overexpressing UBR5. The histogram shows the densitometric analysis of the bands. (G, H) Wound healing and invasion assays in MIA PaCa-2 and BxPC-3 transiently overexpressing UBR5. Data represents mean ± SEM (n = 3 independent biological repeats). **P<0.01; ***P<0.001.

The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.


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