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. 2021 May 13;13(5):1635. doi: 10.3390/nu13051635

Figure 4.

Figure 4

NRT_N0G5IJ significantly decreased HbA1c concentrations in diabetic db/db mice in a hydrolytic-specific manner. (A) The effect of rosiglitazone (15 mg/kg/day), NRT_N0G5IJ (400 mg/kg/day), or raw material (400 mg/kg/day) versus vehicle control on HbA1c concentrations in db/db mice was determined after 4 weeks of treatment. Mice were treated with 400 mg/kg/day of NRT_N0G5IJ, or vehicle by oral gavage. Data are the mean ± SEM (n = 9) after 4 weeks of treatment. (B) The effect of NRT_N0G5IJ and associated unhydrolysed raw material on HbA1c in db/db mice relative to untreated control mice was determined. Mice were treated with 400 mg/kg/day of NRT_N0G5IJ or raw material by oral gavage, or a similar volume (5 mL/kg) of vehicle. Data are the mean ± SEM (n = 9) after 4 weeks of treatment (* p < 0.05, *** p < 0.001).