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. 1988 Jun 1;29(2):255–258. doi: 10.1186/BF03548379

Pancreatic Duct Obstruction in the Pig: Electron Microscopy of Chronic Pancreatitis

Obstruktion av ductus pancreaticus hos svin. En elektronmikroskopisk undersökning av kronisk pankreatit

Timo Rahko 1,✉, Hannu Saloniemi 1, Timo V Kalima 1
PMCID: PMC8152535  PMID: 3223475

Abstract

Ultrastructural alterations of pancreatic tissues in growing pigs caused by surgical ligation of the main pancreatic duct are described. Five animals aged 6 to 7 weeks were operated on and necropsied 2, 6 or 8 weeks later. In addition, 3 pigs that were sham-operated served as controls. Obstruction of the ducts caused progressive luminal dilatations and rupture of intercellular connections of the epithelium followed by destruction and atrophy of acinar parenchyma and proliferations of immature ductular epithelial cells free from zymogen granules.

Keywords: pancreatic duct ligation, exocrine pancreatic insufficiency, experimental chronic pancreatitis, porcine pancreas diseases

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Acknowledgements

Electron microscopial studies were performed in the Laboratory of Electron Microscopy, College of Veterinary Medicine, Helsinki.

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