Skip to main content
NCBI home page
Acta Veterinaria Scandinavica logoLink to Acta Veterinaria Scandinavica
. 1988 Jun 1;29(2):199–206. doi: 10.1186/BF03548371

Influence of the Local Tolerance on the Pharmokinetics of two Penicillin G Preparations in Cattle and Swine

Inverkan av den lokala toleransen hos två penicillin G beredningar på farmakokinetiken hos svin och nötkreatur

Jan Luthman 18,28,✉, Vivi Dali 18,28, S O Jacobsson 18,28, B Bengtsson 18,28, Chr Korpe 18,28
PMCID: PMC8152556  PMID: 3223468

Abstract

The addition of citrate buffer to a penicillin G preparation for injection was in a preliminary study found to improve the local tolerance in rabbits. In the present study 2 penicillin G preparations with different citrate buffer content was tested in the target species swine and cattle. The results of the local tolerance studies indicated that the preparation with the highest citrate content caused less tissue damage. In swine this preparation gave 100% higher maximum levels in serum than the more tissue irritating preparation. In calves the most irritating preparation showed significantly longer half-life. The results indicated that the local tolerance may influence the serum levels in a way that may influence the penetration of penicillin.

Full Text

The Full Text of this article is available as a PDF (985.2 KB).

References

  1. Baggot JD. Principles of Drug Disposition in Domestic Animals. Philadelphia/London/T oronto: W. B. Saunders Co.; 1977. [Google Scholar]
  2. Barza M, Weinstein J. Penetration of antibiotics into fibrin loci in vivo. I. Comparison of penetration into fibrin clots, abscesses and interstitial fluid. J. infect. Dis. 1974;129:59–65. doi: 10.1093/infdis/129.1.59. [DOI] [PubMed] [Google Scholar]
  3. Bengtsson B, Luthman J, Jacobsson SO. Evaluation of a tissue cage model for use in cattle. Acta vet. scand. 1984;25:480–494. doi: 10.1186/BF03546916. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dall V, Luthman J. Improvement of the local tolerance of a potassium penicillin g formulation for injection. Acta vet. scand. 1988;29:101–107. doi: 10.1186/BF03548398. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Diness V. Local tissue damage after intramuscular injections in rabbits and pigs: Quantitation by determination of creatine kinase activity at injection sites. Acta pharmacol. toxicol. 1985;56:410–415. doi: 10.1111/j.1600-0773.1985.tb01311.x. [DOI] [PubMed] [Google Scholar]
  6. Holm SE, Ekedahl C, Bergholm AM. J. infect. Dis. 1978. Comparison of antibiotic assays using different experimental models and their possible clinical significance. Scand; pp. 214–220. [PubMed] [Google Scholar]
  7. Karlbom I, Einarsson S, Edqvist LA. Attainment of puberty in female pigs. Clinical appearance and patterns of progesteron, oestradiol-17ß and LH. Anim. Reprod. Sei. 1981;4:301–312. [Google Scholar]
  8. Luthman J, Bengtsson B, Jacobsson SO. Penetration of antibacterial agents into tissue cage fluid in cattle. Zbl. Vet. Med. A. 1984;31:303–313. doi: 10.1111/j.1439-0442.1984.tb01287.x. [DOI] [PubMed] [Google Scholar]
  9. Luthman J, Jacobsson SO. Distribution of penicillin G in serum and tissue cage fluid in cattle. Acta vet. scand. 1986;27:313–325. doi: 10.1186/BF03548146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. MacDiarmid SC. The absorption of drugs from subcutaneous and intramuscular injection sites. Vet. Bull. 1983;53:9–23. [Google Scholar]
  11. Marshal AB, Palmer GB: Injection sites and drug bioavailability. In Trends in Veterinary Pharmacology and Toxicology. Ed. van Miert, A. S. J. P., J. Frens & J. van der Kreek. Elsevier Scientific Publishing Comp., Amsterdam/Oxford/New York 1980.
  12. Mevius AB, Nouws JFM, Breukink HJ, Vree TB, Driessens F, Verkaik R. Comparative pharmacokinetics, bioavailability and renal clearence of five parenteral oxytetracycline - 20 % formulations in dairy cows. Vet. Quart. 1986;8:285–294. doi: 10.1080/01652176.1986.9694057. [DOI] [PubMed] [Google Scholar]
  13. Rasmussen F, Hogh P. Lokalirritation og koncentrationer pâ injektionsstedet efter intramuskulær injektion af antibiotikaholdige præparater pâ koer og grise. (Irritating effect and concentrations at the injection site after intramuscular injection of antibiotic preparations in cows and pigs) Nord. Vet.-Med. 1971;23:593–605. [Google Scholar]
  14. Rasmussen F, Frens J, van der Kreek J. Tissue damage at the injection site after intramuscular injection of drugs in foodproducing animals. In: van Miert A S J P, editor. Trends in VeterinaryPharmacology and Toxicology. Amsterdam/ Oxford/New York: Elsevier Scientific Publishing Comp.; 1980. [Google Scholar]
  15. Svendsen O, Rasmussen F, Nielsen P, Steiness E. The loss of creatine kinase (CK) from intramuscular injection sites in rabbits. A predictive tool for local toxicity. Acta pharmacol. toxicol. 1979;44:324–328. doi: 10.1111/j.1600-0773.1979.tb02338.x. [DOI] [PubMed] [Google Scholar]
  16. Svendsen O. Local muscle damage and oily vehicles: A study on local reactions in rabbits after intramuscular injection of neuroleptic drugs in aqueous or oily vehicles. Acta pharmacol. toxicol. 1983;52:298–304. doi: 10.1111/j.1600-0773.1983.tb01104.x. [DOI] [PubMed] [Google Scholar]

Articles from Acta Veterinaria Scandinavica are provided here courtesy of BMC

RESOURCES