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. 1988 Mar 1;29(1):43–49. doi: 10.1186/BF03548390

Effect of a Glucocorticoid on the Post-Operative Course Following Experimental Orthopaedic Surgery in Dogs

Effekt av et glucokortikoid på det post-operative forløp etter eksperimentell ortopedisk kirurgi på hunder

S W Mbugua 16,26,36,✉, L A Skoglund 16,26,36, P Skjelbred 16,26,36, P Løkken 16,26,36
PMCID: PMC8152558  PMID: 3202058

Abstract

The capability of a single i.m. injection of betamethasone (Celeston Chronodose®) to modulate a post-operative course was investigated in a placebo-controlled crossover trial with 8 dogs. Two »identical« soft tissue/bone operations were performed on the forelimbs of each animal with an interval of 28 days, to allow a paired comparison of the inflammatory signs and healing process. Significantly less swelling, but not less pain and limping, was observed when the glucocorticoid was administered. No adverse effect of the glucocorticoid was seen on wound and bone healing. The present experimental model is suggested useful for evaluation of anti-inflammatory drug effects in accidental trauma and orthopaedic surgery.

Keywords: betamethasone, post-operative swelling, pain, limping, wound and fracture healing

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Acknowledgement

This work was supported by the Norwegian Agency for International Development (NORAD). The authors are grateful to L. Sandvik, MSc, for performing the statistical analysis.

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