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. 2021 May 14;13(5):724. doi: 10.3390/pharmaceutics13050724

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Evaluation of macroscopic features (A–D) and X-ray (A’–D’) of defects in the femur bone rats (arrows). Groups: G1: Control—no implant; G2: Co—Co-28Cr-6Mo alloy; G3: Co PIII- Co-28Cr-6Mo with surface nanostructured by PIII; G4: Co+Ti PIII—Co-28Cr-6Mo alloy surface coated with Ti and nanostructured by PIII. Macroscopic images do not show any focus of infection or inflammatory process. The radiographic images show correct positioning of the metallic implants (MI) in the G2, G3, G4 groups as well as their radiodensities.